Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927012 | 0.80 | PIK3CG (0.59) | PIK3CDPIK3CBPIK3CGPIK3CAGAA | |
| SCHEMBL926176 | 0.67 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CAGAA | |
| SCHEMBL10119823 | 0.67 | HSD11B1 (0.48) | PIK3CAKDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL5508446 | 0.65 | ATAD2 (0.39) | PIK3CDPIK3CBPIK3CGPIK3CAKDM4E | |
| SCHEMBL926185 | 0.64 | PIK3CG (0.57) | PIK3CDPIK3CBPIK3CGPIK3CAGAA | |
| SCHEMBL925179 | 0.64 | GAA (0.58) | PIK3CDPIK3CBPIK3CGPIK3CAGAA | |
| SCHEMBL4778320 | 0.63 | KMT2A (0.47) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL48824 | 0.63 | ALDH1A1 (0.46) | PIK3CDPIK3CBPIK3CGPIK3CALMNA | |
| SCHEMBL22792087 | 0.63 | KDM4E (0.52) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2835239 | 0.62 | PIK3CG (0.64) | PIK3CGGAAKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841763-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | AstraZeneca AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006051270-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS P13K INHIBITORS | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |