Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD5 | P21918 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3759932 | 0.93 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CDRD2HTR1A | |
| SCHEMBL3759931 | 0.89 | DRD2 (0.48) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL5509179 | 0.88 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CDRD2HTR1A | |
| SCHEMBL5503809 | 0.88 | RBP4 (0.46) | ADRA2AADRA2BADRA2CDRD2DRD1 | |
| SCHEMBL5501921 | 0.84 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CDRD2MEN1 | |
| SCHEMBL2783386 | 0.83 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CDRD2HTR1A | |
| SCHEMBL3764528 | 0.83 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CDRD2HTR1A | |
| SCHEMBL5503801 | 0.83 | DRD2 (0.46) | ADRA2AADRA2BADRA2CDRD2SLC6A4 | |
| SCHEMBL5506603 | 0.82 | DRD2 (0.38) | ADRA2AADRA2BADRA2CDRD2HTR1A | |
| SCHEMBL5525445 | 0.82 | DRD2 (0.38) | ADRA2AADRA2BADRA2CDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768958-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-04 | — | — | EP | claimed |
| WO-2005121088-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |