Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503665 | 0.78 | NR3C1 (0.41) | NR3C1NR3C2PGRKDM4EALDH1A1 | |
| SCHEMBL6009060 | 0.71 | KEAP1 (0.37) | ALDH1A1 | |
| SCHEMBL12722551 | 0.68 | KDM4E (0.50) | NR3C1NR3C2PGRKDM4EALDH1A1 | |
| SCHEMBL3640959 | 0.68 | ACACB (0.52) | NR3C1NR3C2PGRKDM4EALDH1A1 | |
| SCHEMBL18292224 | 0.66 | NR3C1 (0.42) | NR3C1NR3C2PGRKDM4EALDH1A1 | |
| SCHEMBL10895597 | 0.66 | ADRB3 (0.49) | — | |
| SCHEMBL24912886 | 0.65 | ADRB3 (0.48) | NR3C1NR3C2PGRCYP1A2CYP2D6 | |
| SCHEMBL27220689 | 0.65 | ADRB3 (0.56) | NR3C1NR3C2PGR | |
| SCHEMBL27220693 | 0.65 | ADRB3 (0.56) | NR3C1NR3C2PGR | |
| SCHEMBL27220675 | 0.65 | ADRB3 (0.48) | NR3C1NR3C2PGRCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828111-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006059252-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-06-08 | — | — | WO | disclosed |