Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 6/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503942 | 0.80 | KEAP1 (0.36) | KEAP1NFE2L2ACHESTAT3ALDH1A1 | |
| SCHEMBL6008635 | 0.75 | GRIA4 (0.40) | KEAP1NFE2L2CA1CA2GRIA4 | |
| SCHEMBL5506848 | 0.71 | NR3C1 (0.41) | ALDH1A1 | |
| SCHEMBL6009865 | 0.69 | KCNA5 (0.42) | ALDH1A1KMT2ALMNA | |
| SCHEMBL5506849 | 0.69 | GHSR (0.39) | CA1CA2ACHEBCHEALDH1A1 | |
| SCHEMBL6009959 | 0.69 | KEAP1 (0.36) | KEAP1NFE2L2ACHESTAT3ALDH1A1 | |
| SCHEMBL17995187 | 0.64 | KEAP1 (0.39) | KEAP1NFE2L2CA1CA2ACHE | |
| SCHEMBL6008622 | 0.64 | CA1 (0.39) | CA1CA2ALDH1A1CA9CA7 | |
| SCHEMBL5504083 | 0.64 | KEAP1 (0.36) | KEAP1NFE2L2GRIA4ACHESTAT3 | |
| SCHEMBL11041781 | 0.62 | GRIA4 (0.50) | CA1CA2GRIA4ACHESTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183800-A1 | Methods and fluorinated compositions for treating amyloid-related diseases | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183800-A1 | Methods and fluorinated compositions for treating amyloid-related diseases | APP, PSEN1, TTR | KEAP1 1179/4885NFE2L2 2049/4885CA1 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.