Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869732 | 0.86 | ALOX5AP (0.47) | GAARAB9AKDM2BALDH1A1MEN1 | |
| SCHEMBL1869734 | 0.86 | ALOX5AP (0.47) | GAARAB9AKDM2BALDH1A1MEN1 | |
| SCHEMBL5593253 | 0.83 | KDM2B (0.43) | GAARAB9AKDM2BALDH1A1MEN1 | |
| SCHEMBL4982747 | 0.81 | HPGD (0.54) | GAARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL2845267 | 0.78 | GAA (0.45) | GAARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL4755206 | 0.77 | POLB (0.52) | GAARAB9AKDM2BALDH1A1MEN1 | |
| SCHEMBL4972616 | 0.74 | ALDH1A1 (0.49) | GAAKDM2BALDH1A1MEN1KMT2A | |
| SCHEMBL23835159 | 0.72 | PARP10 (0.52) | — | |
| SCHEMBL5593568 | 0.72 | RBP4 (0.41) | RAB9AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5509718 | 0.70 | REN (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101072561-B | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS INC | 2011-05-11 | — | — | CN | disclosed |
| CN-101072561-A | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS INC (US) | 2007-11-14 | — | — | CN | disclosed |
| EP-1807078-A1 | DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006042150-A1 | DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |