Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 10/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869734 | 0.84 | ALOX5AP (0.47) | KDM2BGAARAB9AALDH1A1MEN1 | |
| SCHEMBL1869732 | 0.84 | ALOX5AP (0.47) | KDM2BGAARAB9AALDH1A1MEN1 | |
| SCHEMBL5507540 | 0.83 | GAA (0.46) | KDM2BGAARAB9AALDH1A1POLB | |
| SCHEMBL5318682 | 0.78 | KDM2B (0.49) | KDM2BGAARAB9AALDH1A1KDM4E | |
| SCHEMBL5593263 | 0.73 | GRM5 (0.39) | KDM2BGAARAB9AALDH1A1L3MBTL1 | |
| SCHEMBL3885007 | 0.73 | GAA (0.38) | KDM2BGAARAB9AALDH1A1KDM4E | |
| SCHEMBL23835159 | 0.71 | PARP10 (0.52) | — | |
| SCHEMBL4975598 | 0.70 | MEN1 (0.53) | KDM2BALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5593562 | 0.70 | REN (0.48) | — | |
| SCHEMBL1866539 | 0.69 | ALOX5AP (0.57) | RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |