Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602129 | 0.79 | MGAM (0.48) | ALDH1A1KDM4EMEN1KMT2ACNR2 | |
| SCHEMBL5777774 | 0.77 | IKBKB (0.46) | ALDH1A1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL725183 | 0.70 | MGAM (0.61) | ALDH1A1KDM4EMEN1KMT2ACNR2 | |
| SCHEMBL30208641 | 0.70 | MGAM (0.61) | ALDH1A1KDM4EMEN1KMT2ACNR2 | |
| SCHEMBL8210849 | 0.70 | KDM4E (0.45) | KDM4EMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL178081 | 0.69 | TLR8 (0.42) | ALDH1A1KDM4EMEN1KMT2ACNR2 | |
| SCHEMBL3391383 | 0.69 | HSP90AA1 (0.46) | ALDH1A1KDM4ETSHRHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL16793838 | 0.69 | MGAM (0.59) | ALDH1A1KDM4EMEN1KMT2ACNR2 | |
| Hydrochloric Acid SCHEMBL30615167 | 0.69 | MGAM (0.59) | ALDH1A1KDM4EMEN1KMT2ACNR2 | |
| SCHEMBL7953763 | 0.69 | KDM4E (0.43) | ALDH1A1KDM4EMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39836-E1 | Macrolide antinfective agents | KOSAN BIOSCIENCES, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-RE39591-E1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1171446-B1 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES INC (US) | 2006-09-20 | — | — | EP | disclosed |
| US-6794366-B2 | ERYTHRONOLIDE DERIVATIVES THAT CONTAIN MODIFICATIONS FROM THE NATIVE STRUCTURE AT POSITIONS 13, E.G., 15-(QUINOL-4-YL-ACETAMIDOERYTHROMYCIN A; BACTERICIDES; PRESERVATIVES | KOSAN BIOSCIENCES, INC. | 2004-09-21 | — | — | US | disclosed |
| US-6762168-B2 | ANTIBACTERIAL COMPOUNDS. THE INVENTION CONCERNS MACROLIDE ANTIBIOTICS USEFUL AS ANTIINFECTIVE AGENTS. | KOSAN BIOSCIENCES, INC. | 2004-07-13 | — | — | US | disclosed |
| US-20030207821-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2003-11-06 | — | — | US | disclosed |
| US-6593302-B2 | Antibiotics | KOSAN BIOSCIENCES, INC. | 2003-07-15 | — | — | US | disclosed |
| US-6514944-B2 | Macrolide antibiotics containing an erythronolide nucleus modified at least at the substituent at C-13 | KOSAN BIOSCIENCES, INC. | 2003-02-04 | — | — | US | disclosed |
| US-20020156028-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2002-10-24 | — | — | US | disclosed |
| US-6451768-B1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-09-17 | — | — | US | disclosed |
| US-20020119938-A1 | Macrolide antiinfective agents | CHU DANIEL (US) | 2002-08-29 | — | — | US | disclosed |
| US-6395710-B1 | CONTROLLING INFECTIONS | KOSAN BIOSCIENCES, INC. | 2002-05-28 | — | — | US | disclosed |
| US-20020055472-A1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-05-09 | — | — | US | disclosed |
| EP-1171446-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1171448-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2001049699-A1 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2001-07-12 | — | — | WO | disclosed |
| WO-2000063224-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-2000063225-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156028-A1 | Macrolide antiinfective agents | DOHH, MRPS18B, MRPL21 | ALDH1A1 2959/4885KDM4E 818/4885MEN1 3591/4885 |
| US-20020119938-A1 | Macrolide antiinfective agents | MLNR, DOHH, NOP2 | ALDH1A1 4432/4885KDM4E 1780/4885MEN1 4137/4885 |
| US-20030207821-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | ALDH1A1 3804/4885KDM4E 3657/4885MEN1 3716/4885 |
| US-20020055472-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | ALDH1A1 3804/4885KDM4E 3657/4885MEN1 3716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.