Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 15/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 8/20 | 0.36 |
| ▸ | PPARD | Q03181 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | FABP2 | P12104 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511644 | 0.90 | PPARA (0.42) | HSD11B1PPARACYP1A2CYP3A4PPARG | |
| SCHEMBL5507886 | 0.84 | HSD11B1 (0.50) | HSD11B1PPARAPPARGPPARD | |
| SCHEMBL3004303 | 0.83 | HSD11B1 (0.45) | HSD11B1PDE5AMAP4K4KCNH2MINK1 | |
| SCHEMBL4241676 | 0.75 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL5511640 | 0.75 | HSD11B1 (0.45) | HSD11B1PPARACYP1A2CYP3A4LMNA | |
| SCHEMBL4065127 | 0.74 | HSD11B1 (0.58) | HSD11B1CYP2C9 | |
| SCHEMBL2993657 | 0.73 | PPARA (0.44) | HSD11B1PPARACYP1A2CYP3A4PPARG | |
| SCHEMBL3001199 | 0.71 | FFAR4 (0.43) | HSD11B1CYP2C9 | |
| SCHEMBL2994592 | 0.71 | HSD11B1 (0.43) | HSD11B1MEN1KMT2ATSHR | |
| SCHEMBL4519067 | 0.71 | HSD11B1 (0.50) | HSD11B1KCNH2PPARGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |