Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | FBP1 | P09467 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507891 | 0.90 | HSD11B1 (0.43) | PPARACYP1A2CYP3A4TSHRLMNA | |
| SCHEMBL5511640 | 0.85 | HSD11B1 (0.45) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL2993657 | 0.84 | PPARA (0.44) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL5507886 | 0.75 | HSD11B1 (0.50) | PPARAHSD11B1PPARG | |
| SCHEMBL3004303 | 0.73 | HSD11B1 (0.45) | PPARACYP1A2CYP3A4TSHRLMNA | |
| SCHEMBL4241676 | 0.72 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL2995575 | 0.71 | HSD11B1 (0.44) | TSHRHSD11B1ALDH1A1MAPK1CHRM3 | |
| SCHEMBL2994592 | 0.70 | HSD11B1 (0.43) | TSHRHSD11B1ALDH1A1CNR1OPRK1 | |
| SCHEMBL4514152 | 0.70 | HSD11B1 (0.49) | CYP1A2CYP3A4TSHRLMNAHSD11B1 | |
| SCHEMBL4065127 | 0.69 | HSD11B1 (0.58) | HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |