Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4904007 | 1.00 | PNMT (0.40) | PNMTDRD2DRD1DRD4DRD5 | |
| SCHEMBL4904558 | 0.75 | LIMK1 (0.40) | — | |
| SCHEMBL4905208 | 0.72 | — | — | |
| SCHEMBL10748232 | 0.70 | NR2E1 (0.66) | DRD2DRD1DRD4DRD5DRD3 | |
| Ammonia Solution, Strong SCHEMBL15466738 | 0.69 | DRD2 (0.50) | PNMTDRD2DRD1DRD4DRD5 | |
| SCHEMBL4904164 | 0.68 | PDK1 (0.46) | — | |
| SCHEMBL450863 | 0.68 | DRD2 (0.49) | PNMTDRD2DRD1DRD4DRD5 | |
| SCHEMBL15595295 | 0.68 | DRD2 (0.49) | PNMTDRD2DRD1DRD4DRD5 | |
| SCHEMBL29767754 | 0.68 | DRD2 (0.49) | PNMTDRD2DRD1DRD4DRD5 | |
| SCHEMBL25424691 | 0.67 | DRD2 (0.40) | PNMTDRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | claimed |