SCHEMBL450863

SCHEMBL450863

c1ccc2c3c(sc2c1)CCCC3

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.49
DRD1 P21728 1/20 0.49
DRD4 P21917 1/20 0.49
DRD5 P21918 1/20 0.49
DRD3 P35462 1/20 0.49
GPR3 P46089 1/20 0.46
PNMT P11086 1/20 0.41
ALDH1A1 P00352 3/20 0.40
LMNA P02545 2/20 0.40
HPGD P15428 2/20 0.40
MAPT P10636 2/20 0.40
GAA P10253 1/20 0.40
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
KDM4E B2RXH2 1/20 0.36
NFKB1 P19838 1/20 0.36
CASP3 P42574 1/20 0.36
NFKB2 Q00653 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29767754 1.00 DRD2 (0.49) DRD2DRD1DRD4DRD5DRD3
SCHEMBL15595295 0.96 DRD2 (0.49) DRD2DRD1DRD4DRD5DRD3
Ammonia Solution, Strong SCHEMBL15466738 0.85 DRD2 (0.50) DRD2DRD1DRD4DRD5DRD3
SCHEMBL29292345 0.85 ALDH1A1 (0.44) DRD2DRD1DRD4DRD5DRD3
SCHEMBL15180554 0.80 GPR3 (0.39) DRD2DRD1DRD4DRD5DRD3
SCHEMBL18866963 0.80 GPR3 (0.39) DRD2DRD1DRD4DRD5DRD3
SCHEMBL25294084 0.79 DRD2 (0.45) DRD2DRD1DRD4DRD5DRD3
SCHEMBL30439522 0.79 DRD2 (0.45) DRD2DRD1DRD4DRD5DRD3
SCHEMBL30439911 0.78 DRD2 (0.42) DRD2DRD1DRD4DRD5DRD3
SCHEMBL11881666 0.78 DRD2 (0.42) DRD2DRD1DRD4DRD5DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 455 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113861128-A Polymerizable compound and optically anisotropic body 江苏创拓新材料有限公司 2021-12-31 CN claimed
EP-1852420-B1 Indole compounds for treating respiratory disorders ONO PHARMACEUTICAL CO (JP) 2012-10-17 EP claimed
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 2026-04-14 US disclosed
US-20260083735-A1 ABHD6 ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 2026-03-26 US disclosed
EP-4642875-A1 A PROCESS AND PLANT FOR DESULFURIZING A CRUDE HYDROCARBON COMPOSITION, SUCH AS DIESEL OR KEROSINE Sulzer Management AG (CH) 2025-11-05 EP disclosed
EP-4596555-A1 ABHD6 ANTAGONIST ONO Pharmaceutical Co., Ltd. (JP) 2025-08-06 EP disclosed
US-12275897-B2 Boron doped hydrodesulfurization catalyst KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) 2025-04-15 US disclosed
US-12275898-B2 Hydrodesulfurization reaction composition KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) 2025-04-15 US disclosed
US-12275899-B2 MOCO hydrodesulfurization catalyst KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) 2025-04-15 US disclosed
CN-119524885-A Preparation and application of egg yolk-shell structure phase hydrodesulfurization catalyst based on hydrogen overflow 中国石油大学(华东) 2025-02-28 CN disclosed
US-20250063948-A1 HIGH EFFICIENCY AND LONG LIFETIME ORGANIC LIGHT-EMITTING DIODE SFC CO., LTD. (KR) 2025-02-20 US disclosed
US-5186818-A Hydrodesulfurizatioin and/or hydrodenitrogenation using transition metal compounds in stacked beds having controlled rim to edge ratios EXXON RESEARCH AND ENGINEERING COMPANY (US) 1993-02-16 US disclosed
US-4544481-A HYDROTREATMENT OF HYDROCARBONS EXXON RESEARCH AND ENGINEERING CO. (US) 1985-10-01 US disclosed
US-4542121-A Catalysts from molybdenum polysulfide precursors, their preparation and use EXXON RESEARCH AND ENGINEERING CO. (US) 1985-09-17 US disclosed
US-4540481-A HYDROCARBON HYDROTREATMENT EXXON RESEARCH AND ENGINEERING CO. (US) 1985-09-10 US disclosed
US-4457836-A FROM PETROLEUM DISTILLATES EXXON RESEARCH AND ENGINEERING COMPANY (US) 1984-07-03 US disclosed
US-4431747-A HYDROREFINING CATALYSTS; METHANATION; HYDROTREATMENT; IMPREGNATING WITH A ORGANIC AMINE METAL COMPLEX EXXON RESEARCH AND ENGINEERING CO. (US) 1984-02-14 US disclosed
US-4430442-A HYDROREFINING CATALYSTS; CATALYST SELECTIVETY; HYDRODENITROGENIZATION EXXON RESEARCH AND ENGINEERING CO. (US) 1984-02-07 US disclosed
US-4334078-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS HOFFMANN-LA ROCHE INC. (US) 1982-06-08 US disclosed
US-4219657-A USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1980-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ABHD6, ABHD16A, HDHD5 DRD2 1933/4885DRD1 2073/4885DRD4 2694/4885
US-20260083735-A1 ABHD6 ANTAGONIST ABHD6, ABHD16A, ABHD12 DRD2 1517/4885DRD1 2604/4885DRD4 2397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.