Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775943 | 0.86 | CYP1A2 (0.60) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL5456634 | 0.84 | CYP1A2 (0.67) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL5514406 | 0.83 | LOXL2 (0.51) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL3805296 | 0.82 | CYP1A2 (0.65) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL6670697 | 0.82 | CYP1A2 (0.60) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL25139494 | 0.79 | CYP1A2 (0.57) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL5239658 | 0.79 | CYP1A2 (0.61) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL29987166 | 0.79 | CYP1A2 (0.61) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL5514199 | 0.78 | LOXL2 (0.50) | CYP1A2LOXL2NCF1HTR1AADRA1D | |
| SCHEMBL28001770 | 0.78 | LOXL2 (0.58) | CYP1A2LOXL2NCF1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39836-E1 | Macrolide antinfective agents | KOSAN BIOSCIENCES, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-6794366-B2 | ERYTHRONOLIDE DERIVATIVES THAT CONTAIN MODIFICATIONS FROM THE NATIVE STRUCTURE AT POSITIONS 13, E.G., 15-(QUINOL-4-YL-ACETAMIDOERYTHROMYCIN A; BACTERICIDES; PRESERVATIVES | KOSAN BIOSCIENCES, INC. | 2004-09-21 | — | — | US | disclosed |
| US-6762168-B2 | ANTIBACTERIAL COMPOUNDS. THE INVENTION CONCERNS MACROLIDE ANTIBIOTICS USEFUL AS ANTIINFECTIVE AGENTS. | KOSAN BIOSCIENCES, INC. | 2004-07-13 | — | — | US | disclosed |
| US-20030207821-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2003-11-06 | — | — | US | disclosed |
| US-6593302-B2 | Antibiotics | KOSAN BIOSCIENCES, INC. | 2003-07-15 | — | — | US | disclosed |
| US-6514944-B2 | Macrolide antibiotics containing an erythronolide nucleus modified at least at the substituent at C-13 | KOSAN BIOSCIENCES, INC. | 2003-02-04 | — | — | US | disclosed |
| US-20020156028-A1 | Macrolide antiinfective agents | CHU DANIEL T W (US) | 2002-10-24 | — | — | US | disclosed |
| US-6451768-B1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-09-17 | — | — | US | disclosed |
| US-20020119938-A1 | Macrolide antiinfective agents | CHU DANIEL (US) | 2002-08-29 | — | — | US | disclosed |
| US-6395710-B1 | CONTROLLING INFECTIONS | KOSAN BIOSCIENCES, INC. | 2002-05-28 | — | — | US | disclosed |
| US-20020055472-A1 | Macrolide antiinfective agents | KOSAN BIOSCIENCES, INC. | 2002-05-09 | — | — | US | disclosed |
| EP-1171446-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1171448-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2001049699-A1 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2001-07-12 | — | — | WO | disclosed |
| WO-2000063224-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-2000063225-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156028-A1 | Macrolide antiinfective agents | DOHH, MRPS18B, MRPL21 | CYP1A2 2078/4885LOXL2 1713/4885NCF1 2613/4885 |
| US-20020119938-A1 | Macrolide antiinfective agents | MLNR, DOHH, NOP2 | CYP1A2 2938/4885LOXL2 1782/4885NCF1 480/4885 |
| US-20030207821-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | CYP1A2 1612/4885LOXL2 4266/4885NCF1 560/4885 |
| US-20020055472-A1 | Macrolide antiinfective agents | BECN1, HSPA5, SQSTM1 | CYP1A2 1612/4885LOXL2 4266/4885NCF1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.