Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332665 | 0.83 | PTGES (0.45) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL333920 | 0.82 | KMT2A (0.57) | PTGESMEN1KMT2AMAPTTSHR | |
| SCHEMBL333484 | 0.77 | USP14 (0.45) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL333461 | 0.77 | THRB (0.43) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL334159 | 0.77 | TP53 (0.45) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL333467 | 0.77 | SMN1; SMN2 (0.44) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL334124 | 0.76 | ALOX5 (0.43) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL334103 | 0.75 | PTGES (0.50) | PTGESMEN1KMT2ATP53THRB | |
| SCHEMBL333541 | 0.74 | PPARG (0.47) | PTGESTP53THRBMAPTSMN1; SMN2 | |
| SCHEMBL1407252 | 0.74 | TP53 (0.42) | MEN1KMT2ATP53THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841735-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077366-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |