Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2268223 | 0.85 | CYP2A6 (0.50) | CFTRMAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7680971 | 0.85 | CYP3A4 (0.67) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL17159529 | 0.78 | SMN1; SMN2 (0.42) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL1000233 | 0.78 | SMN1; SMN2 (0.72) | CYP19A1CYP17A1CYP11B1CYP11B2LMNA | |
| SCHEMBL23882924 | 0.77 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL2907043 | 0.77 | CYP19A1 (0.68) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8737044 | 0.77 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL11196968 | 0.77 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL257973 | 0.77 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL1394756 | 0.77 | KMT2A (0.44) | CYP19A1CYP3A4CYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279478-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2007-10-09 | — | — | US | disclosed |
| US-20060122268-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2006-06-08 | — | — | US | disclosed |
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122268-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSK | CYP19A1 1238/4885CYP3A4 3403/4885CYP17A1 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.