Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504988 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TDP1CYP3A4MAPTMEN1 | |
| SCHEMBL10388544 | 0.77 | ALDH1A1 (0.59) | ALDH1A1ADRA2BPTGS1TDP1MAPT | |
| SCHEMBL6069500 | 0.77 | ALDH1A1 (0.46) | ALDH1A1ADRA2BPTGS1TDP1CYP3A4 | |
| SCHEMBL2096172 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CALM1PTPN1MAPT | |
| SCHEMBL18029929 | 0.75 | LTA4H (0.57) | ALDH1A1CYP3A4PTPN1TSHRMAPK1 | |
| SCHEMBL27762002 | 0.74 | ALDH1A1 (0.43) | ALDH1A1ADRA2BPTGS1TDP1MAPT | |
| SCHEMBL6160843 | 0.74 | LTA4H (0.60) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL11037471 | 0.72 | KDM1A (0.43) | ALDH1A1TDP1CYP3A4MAPTMEN1 | |
| SCHEMBL21154654 | 0.72 | NPC1 (0.48) | CALM1PTPN1MAPTMEN1KMT2A | |
| SCHEMBL11198592 | 0.71 | GAA (0.53) | ALDH1A1TDP1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250444-B2 | Pyrrole-based HMG-CoA reductase inhibitors | PFIZER INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-20060287378-A1 | Novel pyrroles and imidazoles | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| EP-1656132-A2 | NOVEL PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS | Warner-Lambert Company LLC (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050043364-A1 | Novel pyrrole-based HMG-CoA reductase inhibitors | KENNEDY ROBERT MICHAEL (US) | 2005-02-24 | — | — | US | disclosed |
| WO-2005014539-A2 | PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043364-A1 | Novel pyrrole-based HMG-CoA reductase inhibitors | HMGCR, DHCR7, HSD17B12 | ALDH1A1 1460/4885ADRA2B 3206/4885PTGS1 219/4885 |
| US-20060287378-A1 | Novel pyrroles and imidazoles | PPIP5K2, PPIE, PPOX | ALDH1A1 2496/4885ADRA2B 2791/4885PTGS1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.