Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527463 | 0.81 | HRH3 (0.52) | HRH3 | |
| SCHEMBL30222295 | 0.79 | DPP4 (0.52) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL25615427 | 0.79 | DPP4 (0.52) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL27301049 | 0.78 | IP6K1 (0.46) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL14597175 | 0.77 | NNMT (0.46) | IP6K1DGAT1KCNH2HRH3 | |
| SCHEMBL2582253 | 0.77 | DPP4 (0.43) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL2695269 | 0.76 | DPP4 (0.53) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL27301167 | 0.76 | HSD11B1 (0.40) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL29483220 | 0.75 | TBK1 (0.48) | IP6K1DPP4DPP9DPP8AXL | |
| SCHEMBL1461328 | 0.75 | TBK1 (0.48) | IP6K1DPP4DPP9DPP8AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8840878-B2 | Peptidomimetic sulfamide compounds and antiviral uses thereof | NOVARTIS AG (CH) | 2014-09-23 | — | — | US | disclosed |
| EP-1697307-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-1697307-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2014-03-12 | — | — | EP | disclosed |
| US-7196100-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196100-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196100-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-03-27 | — | — | US | disclosed |
| US-20070010558-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2007-01-11 | — | — | US | disclosed |
| US-20070010558-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2007-01-11 | — | — | US | disclosed |
| US-20070010558-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2007-01-11 | — | — | US | disclosed |
| EP-1697307-A1 | OPIOID RECEPTOR ANTAGONISTS | Eli Lilly & Company (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061442-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010558-A1 | Opioid receptor antagonists | OPRM1, OPRK1, OPRL1 | IP6K1 3796/4885DPP4 1387/4885DPP9 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.