Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.95 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.95 |
| ▸ | ATM | Q13315 | 1/20 | 0.95 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.59 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.48 |
| ▸ | MGAM | O43451 | 2/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SI | P14410 | 2/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28811644 | 1.00 | POLB (0.95) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Water SCHEMBL12099335 | 1.00 | POLB (0.95) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Water SCHEMBL29396172 | 1.00 | POLB (0.95) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Water SCHEMBL134510 | 1.00 | POLB (0.95) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Water SCHEMBL1915155 | 1.00 | POLB (0.95) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Hydrochloric Acid SCHEMBL17967108 | 0.98 | POLB (0.91) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Water SCHEMBL27491397 | 0.98 | POLB (0.91) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Water SCHEMBL16962408 | 0.98 | POLB (0.91) | POLBMAPK1ATMDGAT1SLC9A1 | |
| Ammonia Solution, Strong SCHEMBL16319213 | 0.98 | POLB (0.91) | POLBMAPK1ATMDGAT1SLC9A1 | |
| SCHEMBL3672275 | 0.98 | POLB (1.00) | POLBMAPK1ATMDGAT1SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 34581 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026104593-A1 | FRAGMENT BASED SYNTHESIS OF PEPTIDES SUCH AS LL37 | NEUROINNOVATECH APS (DK) | 2026-05-21 | — | — | WO | claimed |
| US-12550694-B2 | Selective deposition for integrated circuit interconnect structures | TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD. (TW) | 2026-02-10 | — | — | US | claimed |
| US-20250340518-A1 | PROCESS FOR PREPARATION OF SELUMETINIB AND SALTS THEREOF | GLENMARK LIFE SCIENCES LTD (IN) | 2025-11-06 | — | — | US | claimed |
| EP-4448107-B1 | DRUG DELIVERY SYSTEMS BASED ON ENDOPEROXIDES USEFUL IN DIAGNOSIS AND THERAPY, AND METHODS THEREOF | FACULDADE DE FARMACIA DA UNIV DE LISBOA (PT) | 2025-11-05 | — | — | EP | claimed |
| US-20250250281-A1 | PROCESS FOR PREPARATION OF RELUGOLIX | ALIVUS LIFE SCIENCES LIMITED (IN) | 2025-08-07 | — | — | US | claimed |
| US-20250242576-A1 | HIGH-BARRIER INFLATABLE CUSHION AND PREPARATION PROCESS THEREFOR | Guangzhou Yuanqi Dynamic Technology Co., LTD (CN) | 2025-07-31 | — | — | US | claimed |
| CN-120192356-A | Prazomib preparation process of milnacipse | 上海上药新亚药业有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-115873270-B | Cell-mediated degradation independently controllable gelatin-multi-arm polyethylene glycol hydrogel system and preparation method thereof | 西安交通大学 | 2025-06-17 | — | — | CN | claimed |
| CN-120059439-A | Acylhydrazone bond hydrogel capable of regulating and controlling viscoelasticity as well as preparation method and application thereof | 西安交通大学 | 2025-05-30 | — | — | CN | claimed |
| CN-119978777-A | Modified 6-chloro-1H-pyrazolo [4,3-C ] pyridine-alcohol-containing material and preparation method thereof | 苏州求索生物科技有限公司 | 2025-05-13 | — | — | CN | claimed |
| EP-0346655-B1 | AN IMPROVED METHOD FOR PREPARING POLYMER SURFACES FOR SUBSEQUENT PLATING THEREON, AND IMPROVED METAL-PLATED PLASTIC ARTICLES MADE THEREFROM | GENERAL ELECTRIC COMPANY (US) | 1993-08-18 | — | — | EP | claimed |
| WO-1992020349-A1 | WATER INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES | GENZYME CORPORATION (US) | 1992-11-26 | — | — | WO | claimed |
| EP-0497053-A1 | Improved dry silver constructions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-08-05 | — | — | EP | claimed |
| US-5015555-A | Adhesion, flexibility | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-05-14 | — | — | US | claimed |
| EP-0170414-B1 | PROCESS FOR TREATING METAL SURFACE | Hitachi Chemical Co., Ltd. (JP) | 1991-04-17 | — | — | EP | claimed |
| US-4983567-A | Immunomodulators and methods of making same | BIOMEASURE, INC. (US) | 1991-01-08 | — | — | US | claimed |
| EP-0346655-A1 | An improved method for preparing polymer surfaces for subsequent plating thereon, and improved metal-plated plastic articles made therefrom | GENERAL ELECTRIC COMPANY (US) | 1989-12-20 | — | — | EP | claimed |
| EP-0295833-A1 | Aromatic-Spiropiperidine oxazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1988-12-21 | — | — | EP | claimed |
| US-4643793-A | WITH MIXTURE OF COPPER COMPOUND, COMPLEXING AGENT, REDUCING AGENT, AND PH ADJUSTER IN PRESENCE OF NITROGEN HETEROCYCLE COMPOUND | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1987-02-17 | — | — | US | claimed |
| EP-0170414-A2 | Process for treating metal surface | Hitachi Chemical Co., Ltd. (JP) | 1986-02-05 | — | — | EP | claimed |