Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.75 |
| ▸ | HTR2B | P41595 | 1/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10689625 | 1.00 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL8939573 | 1.00 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL8026168 | 1.00 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL9679215 | 1.00 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL10654017 | 0.97 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| Zinc Ion SCHEMBL8415901 | 0.97 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL9232384 | 0.97 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL8030294 | 0.97 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL9790328 | 0.97 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 | |
| SCHEMBL13727535 | 0.97 | LMNA (0.75) | LMNACYP3A4MAPTMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59027994-A | — | — | None | — | — | JP | disclosed |
| US-7238651-B2 | Process for preparing an overbased detergent | THE LUBRIZOL CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1694802-A1 | PROCESS FOR PREPARING AN OVERBASED DETERGENT | The Lubrizol Corporation (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20060178278-A1 | Process for Preparing an Overbased Detergent | THE LUBRIZOL CORPORATION (US) | 2006-08-10 | — | — | US | disclosed |
| WO-2005042677-A1 | PROCESS FOR PREPARING AN OVERBASED DETERGENT | THE LUBRIZOL CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |
| EP-0719851-B1 | Lubricating oil composition | ASAHI DENKA KOGYO KK (JP) | 2000-02-23 | — | — | EP | disclosed |
| US-5627146-A | A MOLYBDENUM DITHIOCARBAMATE, IMPROVED STABILITY AND SOLUBILITY | ASAHI DENKA KOGYO K.K. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0719851-A2 | Lubricating oil composition | ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) | 1996-07-03 | — | — | EP | disclosed |
| JP-S5927994-A | LUBRICATING OIL COMPOSITION | IDEMITSU KOSAN CO LTD | 1984-02-14 | — | — | JP | disclosed |
| JP-S05927994-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178278-A1 | Process for Preparing an Overbased Detergent | DEGS1, ADH1C, CYP26B1 | LMNA 3459/4885CYP3A4 256/4885MAPT 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.