Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5530482 | 0.82 | GPR119 (0.34) | — | |
| SCHEMBL5524975 | 0.73 | KMT2A (0.38) | MASP2MEN1MAPK1KMT2A | |
| SCHEMBL5135071 | 0.66 | KMT2A (0.34) | MEN1MAPK1KMT2A | |
| SCHEMBL5527997 | 0.65 | PTGES (0.37) | MEN1KMT2AITGB3ITGA2B | |
| SCHEMBL31581462 | 0.64 | CTSS (0.47) | MEN1KMT2AITGB3ITGA2B | |
| SCHEMBL27192552 | 0.63 | CHRM2 (0.33) | MEN1KMT2A | |
| SCHEMBL21001140 | 0.62 | GPR119 (0.42) | MEN1MAPK1KMT2AITGB3ITGA2B | |
| SCHEMBL12385571 | 0.61 | GRIN2B (0.34) | MEN1MAPK1KMT2AITGB3ITGA2B | |
| SCHEMBL2296923 | 0.61 | GRIN2B (0.34) | MEN1MAPK1KMT2AITGB3ITGA2B | |
| SCHEMBL29120582 | 0.61 | CPN1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804793-A2 | 2-(ARYL)AZACYCLYLMETHYL CARBOXYLATES, SULFONATES, PHOSPHONATES, PHOSPHINATES AND HETEROCYCLES AS S1P RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047195-A2 | 2-(ARYL)AZACYCLYLMETHYL CARBOXYLATES, SULFONATES, PHOSPHONATES, PHOSPHINATES AND HETEROCYCLES AS S1P RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2006-05-04 | — | — | WO | disclosed |