SCHEMBL5528804

SCHEMBL5528804

Cc1cc(C(=O)N2CCc3onc(OC(=O)O)c3C2)ccc1Br

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.40
HSP90AA1 P07900 5/20 0.40
TSHR P16473 2/20 0.40
MGLL Q99685 1/20 0.39
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
MTHFD2 P13995 2/20 0.36
ALDH1A1 P00352 2/20 0.35
TP53 P04637 3/20 0.35
MAPT P10636 1/20 0.35
MAPK1 P28482 1/20 0.34
GLA P06280 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5538970 0.87 HSP90AA1 (0.41) HSP90AA1TSHRNPC1RAB9AMTHFD2
SCHEMBL4267339 0.85 HSP90AA1 (0.46) HPGDHSP90AA1TSHRMGLLNPC1
SCHEMBL5527334 0.81 HPGD (0.46) HPGDTSHRNPC1MTHFD2ALDH1A1
SCHEMBL15300348 0.78 HPGD (0.48) HPGDHSP90AA1NPC1RAB9AALDH1A1
SCHEMBL5539180 0.78 HPGD (0.52) HPGDHSP90AA1NPC1RAB9AMTHFD2
SCHEMBL5526654 0.76 ALDH1A1 (0.35) HPGDHSP90AA1NPC1RAB9AALDH1A1
SCHEMBL5532995 0.76 HSD11B1 (0.45) HSP90AA1MGLL
SCHEMBL15300410 0.74 ALDH1A1 (0.47) TSHRNPC1ALDH1A1TP53MAPT
SCHEMBL2586009 0.74 HSP90AA1 (0.53) HPGDHSP90AA1NPC1RAB9AALDH1A1
SCHEMBL15062704 0.73 LMNA (0.50) HPGDHSP90AA1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP claimed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed