Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27306641 | 0.75 | CTSK (0.36) | PDE10ACYP19A1MAPTALDH1A1LMNA | |
| SCHEMBL5357748 | 0.65 | RPS6KB1 (1.00) | RPS6KB1 | |
| SCHEMBL10147185 | 0.65 | KCNH2 (0.45) | ALDH1A1KMT2A | |
| SCHEMBL1301797 | 0.65 | TLR7 (0.36) | TLR7PDE10AMAPTALDH1A1LMNA | |
| SCHEMBL1300750 | 0.65 | TLR7 (0.41) | RPS6KB1TLR7PDE10AMAPTALDH1A1 | |
| SCHEMBL17835018 | 0.64 | BRD4 (0.33) | RPS6KB1 | |
| SCHEMBL12881774 | 0.61 | ALDH1A1 (0.31) | MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5533170 | 0.61 | RPS6KB1 (0.38) | RPS6KB1HRH3MAPTKDM4EMEN1 | |
| SCHEMBL2066236 | 0.58 | PDE10A (0.38) | PDE10ACYP19A1CTSSCTSKKDM4E | |
| SCHEMBL25291538 | 0.58 | RPS6KB1 (0.38) | RPS6KB1CYP19A1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863770-A2 | RING CLOSING AND RELATED METHODS AND INTERMEDIATES | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006121528-A2 | RING CLOSING AND RELATED METHODS AND INTERMEDIATES | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-11-16 | — | — | WO | disclosed |