SCHEMBL5527993

SCHEMBL5527993

CCCCOC(=O)OC(=O)CC1CNC(c2ccc(C#N)cc2)C1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 Q9HC29 1/20 0.36
NOD1 Q9Y239 1/20 0.36
MGLL Q99685 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KCNH2 Q12809 1/20 0.34
S1PR4 O95977 4/20 0.34
S1PR1 P21453 4/20 0.34
S1PR5 Q9H228 4/20 0.34
S1PR3 Q99500 2/20 0.34
DPP4 P27487 2/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
HIF1A Q16665 1/20 0.33
KDM1A O60341 3/20 0.32
HRH2 P25021 1/20 0.32
HRH1 P35367 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5530479 0.82 GPR119 (0.36) L3MBTL1KCNH2S1PR4S1PR1S1PR5
SCHEMBL3495572 0.81 KDM1A (0.38) L3MBTL1KCNH2S1PR4S1PR1S1PR5
SCHEMBL3496533 0.81 KDM1A (0.38) L3MBTL1KCNH2S1PR4S1PR1S1PR5
SCHEMBL3495579 0.81 KDM1A (0.38) L3MBTL1KCNH2S1PR4S1PR1S1PR5
SCHEMBL3495575 0.81 KDM1A (0.38) L3MBTL1KCNH2S1PR4S1PR1S1PR5
SCHEMBL3496531 0.81 KDM1A (0.38) L3MBTL1KCNH2S1PR4S1PR1S1PR5
SCHEMBL5527997 0.75 PTGES (0.37) NOD2NOD1MGLLL3MBTL1KCNH2
SCHEMBL11614790 0.68 RAB9A (0.43) NOD2NOD1MGLLL3MBTL1ALDH1A1
SCHEMBL5524975 0.66 KMT2A (0.38) S1PR4S1PR1S1PR5S1PR3ALDH1A1
Hydrochloric Acid SCHEMBL7273884 0.65 MEN1 (0.44) DPP4MEN1KMT2AKDM1AHRH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1804793-A2 2-(ARYL)AZACYCLYLMETHYL CARBOXYLATES, SULFONATES, PHOSPHONATES, PHOSPHINATES AND HETEROCYCLES AS S1P RECEPTOR AGONISTS Merck & Co., Inc. (US) 2007-07-11 EP disclosed
WO-2006047195-A2 2-(ARYL)AZACYCLYLMETHYL CARBOXYLATES, SULFONATES, PHOSPHONATES, PHOSPHINATES AND HETEROCYCLES AS S1P RECEPTOR AGONISTS MERCK & CO., INC. (US) 2006-05-04 WO disclosed