Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231980 | 0.88 | GPR35 (0.50) | KCNMA1TDP1L3MBTL1TSHRKMT2A | |
| SCHEMBL11591038 | 0.87 | KCNMA1 (0.65) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL9539950 | 0.86 | KCNMA1 (0.57) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL11580623 | 0.86 | KCNMA1 (0.54) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL5144247 | 0.85 | KCNMA1 (0.63) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL30388557 | 0.85 | KCNMA1 (0.63) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL11052201 | 0.83 | KCNMA1 (0.54) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL6653285 | 0.81 | KCNMA1 (0.59) | KCNMA1TDP1L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL5528109 | 0.81 | SMN1; SMN2 (0.43) | KCNMA1TDP1SMN1; SMN2TSHRLMNA | |
| SCHEMBL5520683 | 0.80 | DRD2 (0.59) | L3MBTL1LMNAHTTHSD17B10GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | KCNMA1 1655/4885TDP1 1807/4885L3MBTL1 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.