Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 9/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169614 | 0.92 | MAP3K12 (0.34) | ERCC1FEN1ERCC4MAP3K12 | |
| SCHEMBL1669415 | 0.83 | MAP3K12 (0.32) | MAP3K12 | |
| SCHEMBL1169812 | 0.82 | L3MBTL1 (0.36) | — | |
| SCHEMBL13917571 | 0.79 | ALDH1A1 (0.44) | — | |
| SCHEMBL14310643 | 0.78 | NPSR1 (0.33) | ERCC1FEN1ERCC4MAP3K12 | |
| SCHEMBL13917626 | 0.76 | KCNH2 (0.42) | — | |
| SCHEMBL12225691 | 0.76 | THRB (0.34) | MAP3K12 | |
| SCHEMBL2080839 | 0.76 | CYP3A4 (0.36) | — | |
| SCHEMBL1669208 | 0.76 | MAP3K12 (0.33) | MAP3K12PIK3CAMTOR | |
| SCHEMBL13917568 | 0.76 | LIPG (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749011-A1 | BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005118593-A1 | BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |