Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5531206 | 0.92 | NPC1 (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5528306 | 0.90 | KMT2A (0.47) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL5535769 | 0.89 | GABRP (0.42) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5535174 | 0.87 | MAPT (0.46) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL5530790 | 0.82 | NPC1 (0.43) | NPC1PKMRAB9AMEN1KMT2A | |
| SCHEMBL5531131 | 0.81 | RAB9A (0.47) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4029345 | 0.80 | POLB (0.45) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL5538626 | 0.79 | MAPT (0.57) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3824082 | 0.78 | TUBB4A (0.53) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5528849 | 0.78 | MEN1 (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809279-A1 | NANOPARTICULATE COMPOSITIONS OF TUBULIN INHIBITOR | BAXTER INTERNATIONAL INC. (US) | 2007-07-25 | — | — | EP | claimed |
| WO-2006052712-A1 | NANOPARTICULATE COMPOSITIONS OF TUBULIN INHIBITOR | BAXTER INTERNATIONAL INC. (US) | 2006-05-18 | — | — | WO | claimed |