Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436767 | 0.74 | ALDH1A1 (0.45) | CACNA2D1TLR8TLR7HDAC3HDAC1 | |
| SCHEMBL23929244 | 0.72 | THRB (0.43) | CACNA2D1HDAC1ALDH1A1CYP3A4TSHR | |
| SCHEMBL11045235 | 0.69 | TDP1 (0.42) | CACNA2D1HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL30464709 | 0.68 | HDAC8 (0.43) | CACNA2D1HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL11533028 | 0.68 | HDAC8 (0.43) | CACNA2D1HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL27635962 | 0.68 | HDAC8 (0.43) | CACNA2D1HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL23368385 | 0.68 | CYP11B1 (0.31) | — | |
| SCHEMBL29745004 | 0.68 | HDAC8 (0.43) | CACNA2D1HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL20655979 | 0.68 | HDAC8 (0.43) | CACNA2D1HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL4450758 | 0.67 | TAS1R3 (0.45) | HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205310-B2 | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2005111020-A2 | PYRIMIDINE HYDANTOIN ANALOGUES WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050261324-A1 | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4 | ELAN PHARMACEUTICALS, INC. | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261324-A1 | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4 | VCAM1, ICAM1, LPAR4 | CRHR1 4534/4885CCNA2 970/4885CDK2 459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.