Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291909 | 0.82 | PKM (0.47) | SMN1; SMN2ALDH1A1GAAPKMHPGD | |
| SCHEMBL13384515 | 0.81 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL878178 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1GAAPKMMMP2 | |
| SCHEMBL18918957 | 0.77 | MMP2 (0.46) | SMN1; SMN2MEN1KMT2APKMMAPT | |
| SCHEMBL442293 | 0.75 | MMP2 (0.44) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL5031610 | 0.75 | MMP2 (0.44) | SMN1; SMN2MEN1KMT2AMAPTMMP2 | |
| SCHEMBL9322023 | 0.74 | HDAC1 (0.47) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL15887315 | 0.74 | PKM (0.36) | ALDH1A1MEN1KMT2ATP53PKM | |
| SCHEMBL10215923 | 0.73 | ALDH1A1 (0.48) | ALDH1A1PKMHPGDMAPTNPSR1 | |
| SCHEMBL22559290 | 0.72 | AKT1 (0.43) | ALDH1A1MEN1KMT2ATP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799653-B1 | Condensed thienopyrimidine derivatives for the treatment of cancer | BAYER IP GMBH (DE) | 2013-03-20 | — | — | EP | disclosed |
| EP-1799653-A2 | NOVEL HETEROCYCLES | Bayer Pharmaceuticals Corporation (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006023843-A2 | NOVEL HETEROCYCLES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-02 | — | — | WO | disclosed |