Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5546694 | 0.79 | HTR3A (0.45) | MGLLMCHR1 | |
| SCHEMBL5544987 | 0.76 | PRKAA2 (0.42) | HPGDSPRKAA2HRH3OPRM1DGAT1 | |
| SCHEMBL3533032 | 0.67 | PDGFRB (0.49) | PRKAA2HRH3 | |
| SCHEMBL5546197 | 0.67 | NOD2 (0.39) | HRH3MCHR1SMN1; SMN2 | |
| SCHEMBL5544998 | 0.65 | SIGMAR1 (0.41) | HRH3KCNH2MCHR1 | |
| SCHEMBL5546858 | 0.65 | MEN1 (0.38) | SMN1; SMN2 | |
| SCHEMBL5546920 | 0.64 | HTR3E (0.39) | HPGDSSMN1; SMN2 | |
| SCHEMBL5546568 | 0.64 | CHRM1 (0.38) | PRKAA2HRH3 | |
| SCHEMBL6179704 | 0.62 | KCNQ3 (0.58) | PRKAA2DGAT1SOAT1 | |
| SCHEMBL5540386 | 0.62 | LMNA (0.34) | OPRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |