Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.56 |
| ▸ | CFD | P00746 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017614 | 0.85 | HTT (0.62) | CYP2C19HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL4268296 | 0.85 | MAPT (0.59) | CYP2C19KDM4ELMNAMAPTHPGD | |
| SCHEMBL7404383 | 0.82 | MGLL (0.66) | CYP2C19MGLLHDAC6HDAC1HDAC3 | |
| SCHEMBL14075089 | 0.82 | CYP2C19 (0.57) | CYP2C19MGLLHDAC6HDAC1HDAC3 | |
| SCHEMBL21765474 | 0.81 | SMN1; SMN2 (0.64) | NPC1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL16201549 | 0.80 | MGLL (0.68) | CYP2C19MGLLHDAC6HDAC1HDAC3 | |
| SCHEMBL13476524 | 0.80 | MGLL (0.68) | CYP2C19MGLLHDAC6HDAC1HDAC3 | |
| SCHEMBL10632034 | 0.79 | MAPT (0.60) | NPC1KDM4ELMNAMAPTHPGD | |
| SCHEMBL4003283 | 0.79 | MITF (0.72) | MGLLHDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL8404715 | 0.79 | L3MBTL1 (0.67) | CYP2C19MGLLHDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830858-A2 | 3, 6-BICYCLOLIDES | Enanta Pharmaceuticals, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006063039-A2 | 3, 6-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |