Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5540390 | 0.79 | RAB9A (0.35) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5546861 | 0.71 | NR1H4 (0.38) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3529902 | 0.67 | PDGFRB (0.46) | KMT2AMAPTPOLBKDM4ETP53 | |
| SCHEMBL5546870 | 0.66 | NAMPT (0.34) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5546603 | 0.63 | HPGDS (0.39) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5545017 | 0.60 | ALDH1A1 (0.41) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8404658 | 0.60 | KMT2A (0.81) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5548489 | 0.59 | TUBB4A (0.50) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17078749 | 0.57 | HDAC6 (0.51) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20432728 | 0.57 | HDAC6 (0.51) | KMT2ARAB9ANPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |