Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548484 | 0.89 | KMT2A (0.54) | ALDH1A1KMT2AKDM4EHSD17B10MEN1 | |
| SCHEMBL5540250 | 0.78 | LMNA (0.39) | KMT2AMEN1SMN1; SMN2POLBMAPT | |
| SCHEMBL5546901 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KMT2AKDM4EHSD17B10PKM | |
| SCHEMBL5545055 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL5540347 | 0.74 | CCKAR (0.39) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL5544973 | 0.74 | GAA (0.32) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL5546851 | 0.72 | KMT2A (0.39) | KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL5546890 | 0.71 | KMT2A (0.43) | KMT2AKDM4EMEN1SMN1; SMN2TP53 | |
| SCHEMBL5540364 | 0.70 | CPT2 (0.39) | KMT2AMEN1SMN1; SMN2MAPK1GAA | |
| SCHEMBL5546197 | 0.69 | NOD2 (0.39) | ALDH1A1KMT2AMEN1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |