Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | DRD4 | P21917 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545055 | 0.85 | ALDH1A1 (0.43) | GAAALDH1A1MEN1POLBKMT2A | |
| SCHEMBL5545093 | 0.82 | HSD11B1 (0.35) | OPRM1OPRD1OPRK1MEN1POLB | |
| SCHEMBL5538108 | 0.79 | PKM (0.42) | OPRK1ALDH1A1 | |
| SCHEMBL5548484 | 0.76 | KMT2A (0.54) | GAAALDH1A1MEN1POLBKMT2A | |
| SCHEMBL5540250 | 0.75 | LMNA (0.39) | OPRK1DRD2DRD4MEN1POLB | |
| SCHEMBL5546899 | 0.74 | ALDH1A1 (0.48) | GAAALDH1A1MEN1POLBKMT2A | |
| SCHEMBL5540347 | 0.72 | CCKAR (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5546891 | 0.71 | KMT2A (0.39) | GAAALDH1A1POLBKMT2A | |
| SCHEMBL5546586 | 0.70 | HTR3A (0.41) | PLK1 | |
| SCHEMBL5546858 | 0.67 | MEN1 (0.38) | ALDH1A1MEN1KMT2APLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |