SCHEMBL554704

SCHEMBL554704

O=C(c1ccccc1O)N1CCOCC1

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.67
GAA P10253 2/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
ALDH1A1 P00352 3/20 0.62
NPC1 O15118 2/20 0.60
RAB9A P51151 2/20 0.60
TSHR P16473 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
TP53 P04637 1/20 0.57
KMT2A Q03164 1/20 0.56
HSP90AA1 P07900 2/20 0.55
HSP90AB1 P08238 1/20 0.55
HTT P42858 1/20 0.55
HPGD P15428 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7121916 0.89 SMN1; SMN2 (0.77) GAASMN1; SMN2ALDH1A1TSHRNPSR1
SCHEMBL11718417 0.87 MEN1 (0.61) MGLLGAASMN1; SMN2ALDH1A1RAB9A
SCHEMBL31347868 0.87 MEN1 (0.61) MGLLGAASMN1; SMN2ALDH1A1RAB9A
SCHEMBL29940966 0.83 HTT (0.62) MGLLGAASMN1; SMN2ALDH1A1NPC1
SCHEMBL30203951 0.83 MAPT (0.65) MGLLGAASMN1; SMN2ALDH1A1NPC1
SCHEMBL1008405 0.83 MAPT (0.65) MGLLGAASMN1; SMN2ALDH1A1NPC1
SCHEMBL14511319 0.83 HTT (0.62) MGLLGAASMN1; SMN2ALDH1A1NPC1
SCHEMBL20267430 0.82 GAA (0.73) GAASMN1; SMN2ALDH1A1TSHRNPSR1
SCHEMBL2302971 0.81 MAPT (0.68) GAASMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL4057568 0.81 MAPT (0.68) GAASMN1; SMN2ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8163806-B2 Controlled release of biologically active compounds from multi-armed oligomers BEZWADA BIOMEDICAL, LLC (US) 2012-04-24 US claimed
US-20120010284-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS BEZWADA BIOMEDICAL, LLC (US) 2012-01-12 US claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FIRST WAVE BIO, INC. 2024-03-07 US disclosed
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FIRST WAVE BIO, INC. (US) 2023-10-24 US disclosed
US-11744812-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-09-05 US disclosed
WO-2023118074-A1 COMPRESSIBLE AND FREE FLOWING CO-PROCESSED MESOPOROUS SILICA UNIVERZA V LJUBLJANI (SI) 2023-06-29 WO disclosed
US-20230201143-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2023-06-29 US disclosed
US-20230190684-A1 METHODS OF TREATING COVID-19 WITH A NICLOSAMIDE COMPOUND FIRST WAVE BIO, INC. 2023-06-22 US disclosed
US-20230102999-A1 DEUTERATED NICLOSAMIDE FIRST WAVE BIO, INC. 2023-03-30 US disclosed
US-11564896-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-01-31 US disclosed
EP-1021204-A2 BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 2000-07-26 EP disclosed
US-6024976-A TRANSDERMAL DRUG DELIVERY WITH PRESSURE SENSITIVE ADHESIVE COMPOSITION OF POLYVINYLPYRROLIDONE WITH DRUG IN MULTILAYER PATCH NOVEN PHARMACEUTICALS, INC. (US) 2000-02-15 US disclosed
WO-1999015210-A2 BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 1999-04-01 WO disclosed
US-5719197-A DRUG DELIVERY NOVEN PHARMACEUTICALS, INC. (US) 1998-02-17 US disclosed
US-5656286-A BLEND OF TWO POLYMERS; PRESSURE SENSITIVE ADHESIVE NOVEN PHARMACEUTICALS, INC. (US) 1997-08-12 US disclosed
WO-1996040084-A1 COMPOSITIONS AND METHODS FOR USE OF PRESSURE SENSITIVE ADHESIVE TRANSDERMAL DEVICES CONTAINING A BIOADHESIVE HUMECTANT NOVEN PHARMACEUTICALS, INC. (US) 1996-12-19 WO disclosed
WO-1996040086-A2 COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 1996-12-19 WO disclosed
US-5446070-A Flexible, finite, bioadhesive, therapeutical agent in solid form NOVER PHARMACEUTICALS, INC. (US) 1995-08-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FH, CS, ECHS1 MGLL 1024/4885GAA 3384/4885SMN1; SMN2 1037/4885
US-20230190684-A1 METHODS OF TREATING COVID-19 WITH A NICLOSAMIDE COMPOUND ACE2, ACE, MME MGLL 124/4885GAA 1698/4885SMN1; SMN2 275/4885
US-11744812-B2 Methods of treatment ACE2, ACE, SI MGLL 275/4885GAA 1050/4885SMN1; SMN2 224/4885
US-20230201143-A1 METHODS OF TREATMENT ACE2, ACE, SI MGLL 213/4885GAA 1156/4885SMN1; SMN2 311/4885
US-11564896-B2 Methods of treatment ACE2, ACE, SI MGLL 213/4885GAA 1156/4885SMN1; SMN2 311/4885
US-20120010284-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS MME, AADAC, LGMN MGLL 540/4885GAA 13/4885SMN1; SMN2 3155/4885
US-20230102999-A1 DEUTERATED NICLOSAMIDE FH, IDH2, ECHS1 MGLL 1014/4885GAA 3476/4885SMN1; SMN2 633/4885
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FH, CS, ECHS1 MGLL 1049/4885GAA 3478/4885SMN1; SMN2 1157/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.