Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TYR | P14679 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | TACR2 | P21452 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549149 | 0.87 | ESR1 (0.47) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL1253768 | 0.82 | GPR35 (0.51) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL1253645 | 0.82 | GPR35 (0.51) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL1548128 | 0.82 | GPR35 (0.44) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL27610613 | 0.80 | CYP2A6 (0.44) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL5544113 | 0.79 | MTNR1A (0.51) | ALOX5MAPTMEN1KMT2AGPR35 | |
| SCHEMBL12278324 | 0.78 | GPR35 (0.43) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL12277870 | 0.78 | GPR35 (0.43) | ALOX5CYP3A4TYRTP53MAPT | |
| SCHEMBL10470119 | 0.78 | MTNR1A (0.52) | ALOX5MAPTMEN1KMT2AGPR35 | |
| SCHEMBL9347766 | 0.78 | CYP2A6 (0.55) | TP53MAPTGPR35ALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021492-A1 | e.g. sulfamic acid, 1,2,3,4-tetrahydro-dibenzothiophene-7-yl-1,1-dioxide ester; estrogen-dependent diseases | LABORATOIRE THERAMEX (MC) | 2007-01-25 | — | — | US | disclosed |
| EP-1644350-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004101545-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021492-A1 | e.g. sulfamic acid, 1,2,3,4-tetrahydro-dibenzothiophene-7-yl-1,1-dioxide ester; estrogen-dependent diseases | SULT1E1, SULT1A1, SULT2A1 | ALOX5 312/4885CYP3A4 529/4885TYR 1231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.