Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 4/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5782488 | 0.77 | DYRK1A (0.47) | KIF11L3MBTL1ALDH1A1PTPN5 | |
| SCHEMBL2035839 | 0.77 | KIF11 (0.47) | KIF11MAPK1MAPT | |
| SCHEMBL5548637 | 0.74 | L3MBTL1 (0.42) | KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL3285417 | 0.73 | RIPK1 (0.39) | KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL3282405 | 0.73 | SMN1; SMN2 (0.45) | PDE2ATSHRMAPK1KDM4EALDH1A1 | |
| SCHEMBL5548721 | 0.73 | ALDH1A1 (0.45) | KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL11973806 | 0.73 | MEN1 (0.42) | L3MBTL1ALDH1A1MAPTPTPN5 | |
| SCHEMBL4599434 | 0.72 | — | — | |
| SCHEMBL95846 | 0.72 | KIF11 (0.36) | KIF11PDE2ATSHRMAPK1RAPGEF4 | |
| SCHEMBL5548662 | 0.72 | SMN1; SMN2 (0.40) | PDE2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780211-A2 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1775295-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |