Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5546202 | 0.74 | NOD2 (0.40) | MAPTKMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL5548143 | 0.73 | MAPT (0.43) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL5544949 | 0.70 | ALDH1A1 (0.36) | KMT2AALDH1A1MEN1GAARAB9A | |
| SCHEMBL5545053 | 0.68 | GRM5 (0.39) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL5540828 | 0.64 | MAPT (0.44) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL3528118 | 0.64 | MAPT (0.52) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL16713290 | 0.59 | KMT2A (0.66) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL10504806 | 0.59 | KMT2A (0.72) | MAPTKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL6633899 | 0.59 | PTPN2 (0.75) | MAPTKMT2AALDH1A1MEN1GAA | |
| SCHEMBL18658113 | 0.57 | PTPN1 (0.82) | MAPTKMT2AALDH1A1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |