SCHEMBL5546202

SCHEMBL5546202

O=C(NC1=NCC2=CN(C(=O)c3cc4ccccc4n3S(=O)(=O)c3ccccc3)CCC2=N1)c1ccc(F)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 Q9HC29 1/20 0.40
NOD1 Q9Y239 1/20 0.40
HDAC3 O15379 3/20 0.40
HDAC4 P56524 3/20 0.40
HDAC1 Q13547 3/20 0.40
HDAC7 Q8WUI4 3/20 0.40
HDAC2 Q92769 3/20 0.40
HDAC10 Q969S8 3/20 0.40
HDAC11 Q96DB2 3/20 0.40
HDAC8 Q9BY41 3/20 0.40
HDAC6 Q9UBN7 3/20 0.40
HDAC9 Q9UKV0 3/20 0.40
HDAC5 Q9UQL6 3/20 0.40
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
RORC P51449 2/20 0.35
CCR2 P41597 1/20 0.35
ALOX5 P09917 1/20 0.34
KMT2A Q03164 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5546197 0.77 NOD2 (0.39) NOD2NOD1HDAC3HDAC4HDAC1
SCHEMBL5548146 0.74 MAPT (0.48) ALDH1A1LMNAMAPTKMT2AMEN1
SCHEMBL5548489 0.71 TUBB4A (0.50) ALDH1A1LMNAMAPTKMT2AMEN1
SCHEMBL3530540 0.70 HSP90AB1 (0.44) NOD2NOD1HDAC3HDAC4HDAC1
SCHEMBL20417790 0.69 HDAC3 (0.65) NOD2NOD1HDAC3HDAC4HDAC1
SCHEMBL5546901 0.69 ALDH1A1 (0.51) ALDH1A1MAPTKMT2APOLB
SCHEMBL5540828 0.67 MAPT (0.44) ALDH1A1LMNAMAPTRORCKMT2A
SCHEMBL5548741 0.67 SMN1; SMN2 (0.41) ALDH1A1LMNAMAPTKMT2AMEN1
SCHEMBL5545017 0.65 ALDH1A1 (0.41) HDAC1HDAC8HDAC6ALDH1A1LMNA
SCHEMBL5546164 0.65 ALDH1A1 (0.34) HDAC3HDAC1HDAC2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007534719-A 2007-11-29 JP claimed
EP-1742925-A1 SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS Grünenthal GmbH (DE) 2007-01-17 EP claimed
WO-2005105759-A1 SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS Grünenthal GmbH (DE) 2005-11-10 WO claimed