Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.49 |
| ▸ | NPC1 | O15118 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 3/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551743 | 0.80 | IDO1 (0.45) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL346441 | 0.80 | TP53 (0.43) | RAB9ANPC1SMN1; SMN2TP53KDM4E | |
| SCHEMBL5551741 | 0.80 | DYRK1A (0.56) | RAB9ANPC1SMN1; SMN2TP53TDP1 | |
| SCHEMBL2207084 | 0.79 | NPC1 (0.42) | RAB9ANPC1SMN1; SMN2TP53CASP3 | |
| SCHEMBL30206 | 0.78 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2TP53CASP3 | |
| SCHEMBL2171160 | 0.76 | CASP3 (0.47) | RAB9ANPC1SMN1; SMN2CASP3HPGD | |
| SCHEMBL28842353 | 0.75 | SPHK2 (0.42) | RAB9ANPC1L3MBTL1TDP1MAPK1 | |
| SCHEMBL3766697 | 0.73 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2TP53CASP3 | |
| SCHEMBL1567919 | 0.73 | SMN1; SMN2 (0.47) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL29040320 | 0.71 | PDE4A (0.49) | RAB9ANPC1SMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304070-B2 | A2B adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2007-12-04 | — | — | US | claimed |
| US-20050101778-A1 | A2B adenosine receptor antagonists | GILEAD SCIENCES, INC. | 2005-05-12 | — | — | US | claimed |
| WO-2000020414-A9 | PIPERIDYLOXADIAZOLES AS DOPAMINE RECEPTOR ANTAGONISTS | COMBICHEM INC (US) | 2002-08-22 | — | — | WO | disclosed |
| WO-2000020414-A1 | PIPERIDYLOXADIAZOLES AS DOPAMINE RECEPTOR ANTAGONISTS | COMBICHEM, INC. (US) | 2000-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101778-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA1 | RAB9A 1704/4885NPC1 2702/4885SMN1; SMN2 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.