Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.38 |
| ▸ | RELA | Q04206 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357427 | 0.80 | MAPT (0.42) | RAB9ANPC1NOTUMSMN1; SMN2NFKB1 | |
| SCHEMBL2207084 | 0.78 | NPC1 (0.42) | RAB9ANPC1MAPK1NR1H4NOTUM | |
| SCHEMBL345759 | 0.78 | NOTUM (0.44) | RAB9ANPC1NR1H4NOTUMSMN1; SMN2 | |
| SCHEMBL345937 | 0.78 | NPC1 (0.39) | RAB9ANPC1NOTUMSMN1; SMN2POLB | |
| SCHEMBL1435746 | 0.78 | ALDH1A1 (0.53) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL5548164 | 0.78 | RAB9A (0.49) | RAB9ANPC1MAPK1SMN1; SMN2NFKB1 | |
| SCHEMBL346441 | 0.77 | TP53 (0.43) | RAB9ANPC1NOTUMSMN1; SMN2TP53 | |
| SCHEMBL5551743 | 0.77 | IDO1 (0.45) | RAB9ANPC1NOTUMSMN1; SMN2NFKB1 | |
| SCHEMBL5552048 | 0.74 | S1PR1 (0.45) | NOTUMPOLBCHUKCASP3TXNRD1 | |
| SCHEMBL5548169 | 0.74 | NOTUM (0.41) | NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 425 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240034737-A1 | Heterocyclic Derivatives as P2X7 Receptor Antagonists | BREYE THERAPEUTICS APS (DK) | 2024-02-01 | — | — | US | claimed |
| EP-4262975-A1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | Breye Therapeutics ApS (DK) | 2023-10-25 | — | — | EP | claimed |
| WO-2022129365-A1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | AXXAM S.P.A. (IT) | 2022-06-23 | — | — | WO | claimed |
| EP-4015039-A1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | AXXAM S.p.A. (IT) | 2022-06-22 | — | — | EP | claimed |
| US-20180327396-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | claimed |
| EP-3126359-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2017-02-08 | — | — | EP | claimed |
| US-20160376262-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-12-29 | — | — | US | claimed |
| WO-2015150440-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-08 | — | — | WO | claimed |
| US-20110269761-A1 | ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-03 | — | — | US | claimed |
| EP-1441719-B1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-30 | — | — | EP | claimed |
| WO-1995019956-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | claimed |
| EP-0662962-A1 | SUBSTITUTED PYRIMIDINES FOR CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1995-07-19 | — | — | EP | claimed |
| US-5403363-A | Applying to textile material for printing and dyeing; colorfastness | BASF AKTIENGESELLSCHAFT (DE) | 1995-04-04 | — | — | US | claimed |
| EP-0601439-A2 | Dye mixtures containing dyes with a coupling component of the diaminopyridine type | BASF Aktiengesellschaft (DE) | 1994-06-15 | — | — | EP | claimed |
| WO-1994007867-A1 | SUBSTITUTED PYRIMIDINES FOR CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1994-04-14 | — | — | WO | claimed |
| EP-0582643-A1 | PYRIDAZINONE ACETIC ACIDS | PFIZER INC. (US) | 1994-02-16 | — | — | EP | claimed |
| WO-1992017446-A2 | PYRIDAZINONE ACETIC ACIDS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1992-10-15 | — | — | WO | claimed |
| EP-0275821-B1 | SUBSTITUTED ALKANEDIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1992-02-26 | — | — | EP | claimed |
| US-4113937-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1978-09-12 | — | — | US | claimed |
| US-4113938-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1978-09-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240034737-A1 | Heterocyclic Derivatives as P2X7 Receptor Antagonists | P2RX7, P2RX3, P2RX1 | RAB9A 2782/4885NPC1 817/4885MAPK1 896/4885 |
| US-20110269761-A1 | ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | SULT2A1, UGT1A1, SLC5A1 | RAB9A 2091/4885NPC1 1879/4885MAPK1 1276/4885 |
| US-20180327396-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS4, NDUFV1 | RAB9A 2378/4885NPC1 1807/4885MAPK1 747/4885 |
| US-20160376262-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS4, NDUFV1 | RAB9A 2378/4885NPC1 1807/4885MAPK1 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.