Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | POLR1A | O95602 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548632 | 0.87 | KDM1A (0.40) | KAT2BPDE3BPDE3APOLR1A | |
| SCHEMBL5545569 | 0.85 | DRD2 (0.41) | LMNA | |
| SCHEMBL5543674 | 0.84 | PRMT5 (0.42) | — | |
| SCHEMBL5549262 | 0.82 | PRKCQ (0.34) | KAT2BEDNRA | |
| SCHEMBL5550007 | 0.80 | KAT2B (0.39) | KAT2B | |
| SCHEMBL5548887 | 0.79 | KAT2B (0.40) | KAT2B | |
| SCHEMBL5550145 | 0.79 | SLC2A1 (0.42) | LMNA | |
| SCHEMBL5549838 | 0.78 | PGK1 (0.40) | KAT2B | |
| SCHEMBL5549427 | 0.76 | JAK2 (0.31) | — | |
| SCHEMBL5545643 | 0.76 | GSK3B (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |