Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549838 | 0.84 | PGK1 (0.40) | — | |
| SCHEMBL5549394 | 0.81 | PGK1 (0.39) | FGFR1 | |
| SCHEMBL5550007 | 0.81 | KAT2B (0.39) | CYP3A4TSHRMEN1KMT2A | |
| SCHEMBL5548887 | 0.80 | KAT2B (0.40) | CYP3A4TSHRMEN1KMT2A | |
| SCHEMBL3526664 | 0.79 | GAA (0.45) | LMNAKDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL5549024 | 0.79 | KAT2B (0.41) | LMNA | |
| SCHEMBL5548632 | 0.78 | KDM1A (0.40) | MEN1KMT2A | |
| SCHEMBL5545569 | 0.76 | DRD2 (0.41) | LMNAKDM4EHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL3521844 | 0.76 | MAT2A (0.38) | KDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL5545560 | 0.76 | GSK3A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |