Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 9/20 | 0.33 |
| ▸ | GSK3A | P49840 | 7/20 | 0.32 |
| ▸ | GSK3B | P49841 | 7/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529268 | 0.80 | ADORA1 (0.37) | GSK3AGSK3B | |
| SCHEMBL5549838 | 0.73 | PGK1 (0.40) | GSK3AGSK3B | |
| SCHEMBL5543567 | 0.73 | ADORA1 (0.47) | GSK3AGSK3B | |
| SCHEMBL3528788 | 0.73 | GSK3B (0.34) | GSK3AGSK3B | |
| SCHEMBL3524574 | 0.72 | GSK3B (0.32) | GSK3AGSK3B | |
| SCHEMBL5545429 | 0.71 | GSK3B (0.46) | GSK3AGSK3B | |
| SCHEMBL4072562 | 0.70 | AAK1 (0.38) | CCNE2CCNE1CDK2METAP2BRD4 | |
| SCHEMBL5548616 | 0.70 | CA12 (0.40) | GSK3AGSK3B | |
| SCHEMBL5549261 | 0.69 | KMT2A (0.48) | — | |
| SCHEMBL3526413 | 0.69 | PKM (0.42) | GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |