Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL2542900 | 1.00 | GAA (0.62) | — | |
| SCHEMBL6403 | 0.97 | — | — | |
| SCHEMBL30800905 | 0.97 | GAA (0.65) | — | |
| SCHEMBL16698948 | 0.95 | — | — | |
| Alcohol SCHEMBL9306984 | 0.95 | GAA (0.62) | — | |
| Ammonia Solution, Strong SCHEMBL3152412 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL2655390 | 0.95 | — | — | |
| Acetic Acid SCHEMBL6226254 | 0.93 | GAA (0.54) | — | |
| Acetone SCHEMBL8627214 | 0.92 | GAA (0.59) | — | |
| Acetonitrile SCHEMBL7197171 | 0.91 | GAA (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 249 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116726019-A | Preparation method and application of indole diketopiperazine alkaloid | 南方医科大学 | 2023-09-12 | — | — | CN | claimed |
| CN-114560831-A | Dihydrofuranone derivative and extraction method and application thereof | 陕西科技大学 | 2022-05-31 | — | — | CN | claimed |
| CN-111559999-B | Lactone compound and extraction method and application thereof | 陕西科技大学 | 2022-02-08 | — | — | CN | claimed |
| CN-111559999-A | Lactone compound and extraction method and application thereof | 陕西科技大学 | 2020-08-21 | — | — | CN | claimed |
| CN-108383811-B | Furanone derivative and extraction method and application thereof | 陕西科技大学 | 2020-05-12 | — | — | CN | claimed |
| CN-108383824-B | Benzopyrone dimer and extraction method and application thereof | 陕西科技大学 | 2020-04-21 | — | — | CN | claimed |
| CN-108640896-B | A kind of Desertorin B and its extracting method and application | 陕西科技大学 | 2019-07-02 | — | — | CN | claimed |
| CN-108503616-B | A kind of bicoumarin derivative and its extracting method and application | 陕西科技大学 | 2019-07-02 | — | — | CN | claimed |
| CN-109053564-A | The asymmetric piperidines ketone compound and preparation method thereof that N- benzenesulfonyl replaces | 滨州医学院 | 2018-12-21 | — | — | CN | claimed |
| CN-108997311-A | Bis- aryl methylene -4- the piperidones of 3,5- and preparation method thereof that asymmetric 4- pyridine replaces | 滨州医学院 | 2018-12-14 | — | — | CN | claimed |
| CN-108997310-A | Bis- aryl methylene -4- the piperidones of 3,5- and preparation method thereof that asymmetric 3- pyridine replaces | 滨州医学院 | 2018-12-14 | — | — | CN | claimed |
| CN-108640896-A | A kind of Desertorin B and its extracting method and application | 陕西科技大学 | 2018-10-12 | — | — | CN | claimed |
| CN-108503616-A | A kind of bicoumarin derivative and its extracting method and application | 陕西科技大学 | 2018-09-07 | — | — | CN | claimed |
| CN-108383811-A | A kind of furanone derivatives and its extracting method and application | 陕西科技大学 | 2018-08-10 | — | — | CN | claimed |
| CN-108383824-A | A kind of benzopyrone dimer and its extracting method and application | 陕西科技大学 | 2018-08-10 | — | — | CN | claimed |
| CN-102114013-B | Compound inhibiting angiogenesis and preparation method and application thereof | SHANDONG ACADEMY OF SCIENCES CHINA JAPAN FRIENDSHIP CT FOR BIOTECHNOLOGY | 2012-09-26 | — | — | CN | claimed |
| CN-102114013-A | Compound inhibiting angiogenesis and preparation method and application thereof | SHANDONG ACADEMY OF SCIENCES CHINA JAPAN FRIENDSHIP CT FOR BIOTECHNOLOGY | 2011-07-06 | — | — | CN | claimed |
| CN-1303052-C | Process for preparing Danshensu | DALIAN CHEMICAL PHYSICS INST (CN) | 2007-03-07 | — | — | CN | claimed |
| CN-1670008-A | Process for preparing Danshensu | DALIAN CHEMICAL PHYSICS INST (CN) | 2005-09-21 | — | — | CN | claimed |
| EP-4397322-A1 | INHIBITOR OF PROSTATE SPECIFIC MEMBRANE ANTIGEN AND PHARMACEUTICAL USE THEREOF | Tianjin Hengrui Medicine Co., Ltd. (CN) | 2024-07-10 | — | — | EP | disclosed |
| US-20240209004-A1 | BORIC ACID DERIVATIVE ACTING AS Beta-LACTAMASE INHIBITOR | TUOJIE BIOTECH (SHANGHAI) CO., LTD. (CN) | 2024-06-27 | — | — | US | disclosed |
| US-20240189438-A1 | DRUG CONJUGATE OF GLUCOCORTICOID RECEPTOR AGONIST, AND APPLICATION THEREOF IN MEDICINE | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2024-06-13 | — | — | US | disclosed |
| WO-2024104331-A1 | PRODRUG OF LEVODOPA | 江苏恒瑞医药股份有限公司 | 2024-05-23 | — | — | WO | disclosed |
| WO-2024088296-A1 | PIPERIDINOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 上海拓界生物医药科技有限公司 | 2024-05-02 | — | — | WO | disclosed |
| US-20240132518-A1 | CEPHALOSPORIN ANTIBACTERIAL COMPOUND AND PREPARATION METHOD THEREFOR | SHANGHAI SENHUI MEDICINE CO., LTD. (CN) | 2024-04-25 | — | — | US | disclosed |
| CN-115043892-B | Glycosyl polyether compounds targeting actin | 武汉合生科技有限公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-4349851-A1 | METHOD FOR PREPARING ANIDULAFUNGIN DERIVATIVE | Shanghai Senhui Medicine Co., Ltd. (CN) | 2024-04-10 | — | — | EP | disclosed |
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2024-04-04 | — | — | US | disclosed |
| CN-117615795-A | Inhibitors of prostate specific membrane antigen and medical application thereof | 天津恒瑞医药有限公司 | 2024-02-27 | — | — | CN | disclosed |
| EP-4324837-A1 | BORIC ACID DERIVATIVE ACTING AS BETA-LACTAMASE INHIBITOR | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2024-02-21 | — | — | EP | disclosed |
| CN-114539225-B | 2-amino-pyrimidines | 上海拓界生物医药科技有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20240025892-A1 | SALT INDUCIBLE KINASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION | 2024-01-25 | — | — | US | disclosed |
| CN-117427143-A | Pharmaceutical composition containing peptidomimetic compounds and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-117327589-A | Pochonia chlamydosporia PC-170 and application thereof | 中国农业科学院蔬菜花卉研究所 | 2024-01-02 | — | — | CN | disclosed |
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |
| CN-117285589-A | Deuterated peptidomimetic compounds in crystalline form and uses thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-117255797-A | Preparation method of anidulafungin derivative | 上海森辉医药有限公司 | 2023-12-19 | — | — | CN | disclosed |
| EP-4289857-A1 | DRUG CONJUGATE OF GLUCOCORTICOID RECEPTOR AGONIST, AND APPLICATION THEREOF IN MEDICINE | Shanghai Senhui Medicine Co., Ltd. (CN) | 2023-12-13 | — | — | EP | disclosed |
| CN-117205296-A | Protease inhibition compound and application of composition thereof in preparation of cat infectious peritonitis medicines | 嘉兴安谛康生物科技有限公司 | 2023-12-12 | — | — | CN | disclosed |
| EP-4279491-A1 | CEPHALOSPORIN ANTIBACTERIAL COMPOUND AND PREPARATION METHOD THEREFOR | Shanghai Senhui Medicine Co., Ltd. (CN) | 2023-11-22 | — | — | EP | disclosed |
| CN-117003673-A | Prodrugs of levodopa | 江苏恒瑞医药股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| US-20230348371-A1 | SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116917298-A | Boric acid derivatives as beta-lactamase inhibitors | 上海拓界生物医药科技有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-114601828-B | Arenaria kansuensis extract and application thereof in preparing anti-inflammatory drugs | 中国科学院西北高原生物研究所 | 2023-10-03 | — | — | CN | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-116763898-A | Application of protease inhibitor compound in preparation of cat coronavirus infection medicines | 北京科翔中升医药科技有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-116761820-A | Pharmaceutical conjugates of glucocorticoid receptor agonists and their use in medicine | 上海森辉医药有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-116726019-A | Preparation method and application of indole diketopiperazine alkaloid | 南方医科大学 | 2023-09-12 | — | — | CN | disclosed |
| CN-116669734-A | Crystal form of pyrimido five-membered nitrogen heterocyclic derivative and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2023143351-A1 | DRUG CONJUGATE OF GLUCOCORTICOID | 上海盛迪医药有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-116528874-A | Cefprozil antibacterial compound and preparation method thereof | 上海森辉医药有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-113173854-B | Preparation method of chiral beta-acyloxy carboxylic ester compound | 中国科学院上海有机化学研究所 | 2023-07-07 | — | — | CN | disclosed |
| US-11692004-B2 | Substituted pyrazole compound, preparation method therefor, pharmaceutical composition and medical use thereof | JIANGSU VANGUARD PHARMACEUTICAL CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
| CN-108191742-B | 4-acetamidobenzenesulfonyl-substituted 3, 5-diarylmethylene-4-piperidone compound and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-116333523-A | Dendritic N-alkoxy hindered amine light stabilizer, preparation method and application thereof | 天津利安隆新材料股份有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-108191750-B | 3, 5-diarylmethylene-N-benzenesulfonyl-4-piperidone compound and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108997310-B | Asymmetric 3-pyridine substituted 3, 5-diarylmethylene-4-piperidone and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108191751-B | 4-fluorobenzenesulfonyl substituted 3, 5-diarylmethylene-4-piperidone compound and preparation method thereof | 滨州医学院 | 2023-06-27 | — | — | CN | disclosed |
| CN-108997311-B | Asymmetric 4-pyridine substituted 3, 5-diarylmethylene-4-piperidone and preparation method thereof | 滨州医学院 | 2023-06-23 | — | — | CN | disclosed |
| CN-113121398-B | Arylalkylamine compound, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2023-06-20 | — | — | CN | disclosed |
| EP-4192459-A1 | SALT INDUCIBLE KINASE INHIBITORS | The General Hospital Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-116234549-A | Salt-induced kinase inhibitors | 总医院公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-113912601-B | Novel imidazo [1,2-a ] pyridine derivatives, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2023-06-06 | — | — | CN | disclosed |
| EP-4183774-A1 | SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF | Shanghai Senhui Medicine Co., Ltd. (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-114426568-B | 2-oxo-3-pyrrolidinyl propionitrile compounds, pharmaceutical composition and application thereof | 嘉兴安谛康生物科技有限公司 | 2023-04-25 | — | — | CN | disclosed |
| US-20230121689-A1 | CEPHALOSPORIN ANTIBACTERIAL COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI SHENGDI PHARMACEUTICAL CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| CN-115869303-A | Use of sulfonylureas derivatives for treating diseases | 上海森辉医药有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-115836050-A | Sulfonylurea derivative and medical application thereof | 上海森辉医药有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-110214135-B | Indanyl amino pyrazinyl cyclopropane carboxylic acid, pharmaceutical composition and application thereof | 勃林格殷格翰国际有限公司 | 2023-02-21 | — | — | CN | disclosed |
| CN-115583984-A | Azaspiro compound and preparation method, pharmaceutical composition and application thereof | 嘉兴安谛康生物科技有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-110857285-B | Substituted pyrazole compound, preparation method, pharmaceutical composition and application thereof | 江苏万高药业股份有限公司 | 2022-12-20 | — | — | CN | disclosed |
| WO-2022253297-A1 | METHOD FOR PREPARING ANIDULAFUNGIN DERIVATIVE | 上海森辉医药有限公司 | 2022-12-08 | — | — | WO | disclosed |
| CN-113549068-B | Novel imidazopyridine compound, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2022-12-02 | — | — | CN | disclosed |
| US-20220380385-A1 | PYRIMIDINE FIVE-MEMBERED NITROGEN HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | TUOJIE BIOTECH(SHANGHAI) CO., LTD. (CN) | 2022-12-01 | — | — | US | disclosed |
| CN-115385983-A | Azabicyclo compound, preparation method, pharmaceutical composition and application thereof | 嘉兴安谛康生物科技有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115197245-A | Kras inhibitor and preparation method thereof | 上海拓界生物医药科技有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-115043892-A | Actin-targeting glycosyl polyether compounds | 武汉合生科技有限公司 | 2022-09-13 | — | — | CN | disclosed |
| WO-2022166779-A1 | DRUG CONJUGATE OF GLUCOCORTICOID RECEPTOR AGONIST, AND APPLICATION THEREOF IN MEDICINE | 上海森辉医药有限公司 | 2022-08-11 | — | — | WO | disclosed |
| CN-114846016-A | Cephalosporin antibacterial compound and application thereof in medicine | 上海森辉医药有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114805312-A | Ketohexokinase inhibitor and preparation method thereof | 上海拓界生物医药科技有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-114773314-A | Biarylaminoguanidine derivative | 上海拓界生物医药科技有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114763339-A | Process for the preparation of triazine derivatives | 江苏恒瑞医药股份有限公司 | 2022-07-19 | — | — | CN | disclosed |
| CN-114716504-A | Growth hormone secretagogue derivative and preparation method thereof | 上海拓界生物医药科技有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| CN-114671894-A | Salt and crystal form of pyrimido five-membered nitrogen heterocyclic derivative and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-114601828-A | Ganoderma atrum extract and application thereof in preparing anti-inflammatory drugs | 中国科学院西北高原生物研究所 | 2022-06-10 | — | — | CN | disclosed |
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-114560831-A | Dihydrofuranone derivative and extraction method and application thereof | 陕西科技大学 | 2022-05-31 | — | — | CN | disclosed |
| CN-114560831-A | Dihydrofuranone derivative and extraction method and application thereof | 陕西科技大学 | 2022-05-31 | — | — | CN | disclosed |
| CN-114539225-A | 2-amino-pyrimidines | 上海拓界生物医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-109053564-B | N-benzenesulfonyl substituted asymmetric piperidone compounds and preparation method thereof | 滨州医学院 | 2022-05-24 | — | — | CN | disclosed |
| EP-3102207-B1 | 2,4,5-TRI-SUBSTITUTED AZOLE-BASED CASEIN KINASE 1 INHIBITORS AS INDUCERS FOR CARDIOMYOGENESIS | AGENCY SCIENCE TECH & RES (SG) | 2022-05-11 | — | — | EP | disclosed |
| EP-3991731-A1 | PYRIMIDINE FIVE-MEMBERED NITROGEN HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2022-05-04 | — | — | EP | disclosed |
| CN-114426568-A | 2-oxo-3-pyrrolidinylpropionitrile compound, and pharmaceutical composition and application thereof | 安帝康（无锡）生物科技有限公司 | 2022-05-03 | — | — | CN | disclosed |
| CN-112574212-B | Pyrimido five-membered nitrogen heterocyclic derivative, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |
| US-20220073521-A1 | PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF | TUOJIE BIOTECH (SHANGHAI) CO., LTD. (CN) | 2022-03-10 | — | — | US | disclosed |
| CN-111559999-B | Lactone compound and extraction method and application thereof | 陕西科技大学 | 2022-02-08 | — | — | CN | disclosed |
| CN-111559999-B | Lactone compound and extraction method and application thereof | 陕西科技大学 | 2022-02-08 | — | — | CN | disclosed |
| CN-113912601-A | Novel imidazo [1,2-a ] pyridine derivatives, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-113906019-A | Compound and use thereof | 优曼尼蒂治疗公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-113840603-A | Pyrimido five-membered nitrogen heterocyclic derivative, preparation method and application thereof in medicine | 上海拓界生物医药科技有限公司 | 2021-12-24 | — | — | CN | disclosed |
| CN-113795491-A | Bridged ring-3, 4-dihydro-pyrido [1,2-a ] pyrazine-1, 8-dione compound and pharmaceutical use thereof | 上海拓界生物医药科技有限公司 | 2021-12-14 | — | — | CN | disclosed |
| CN-107266505-B | Tetradentate ring metal platinum (II) complex phosphorescence luminescent material | 浙江工业大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-113549068-A | Novel imidazopyridine compound, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2021-10-26 | — | — | CN | disclosed |
| EP-3889153-A1 | PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF | Tuojie Biotech (Shanghai) Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |
| CN-113474348-A | Substituted oxopyridine derivatives | 拜耳公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-109983015-B | 6-pyrazole- [1,2,4] triazolo [4,3-a ] pyridine-3-amide derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-113272303-A | Pyrimido five-membered nitrogen heterocyclic derivative, preparation method and application thereof in medicine | 上海拓界生物医药科技有限公司 | 2021-08-17 | — | — | CN | disclosed |
| WO-2021147986-A1 | CEPHALOSPORIN ANTIBACTERIAL COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF | 上海森辉医药有限公司 | 2021-07-29 | — | — | WO | disclosed |
| CN-113173854-A | Preparation method of chiral beta-acyloxy carboxylic ester compound | 中国科学院上海有机化学研究所 | 2021-07-27 | — | — | CN | disclosed |
| CN-113121398-A | Aryl alkylamine compound, preparation method and application thereof in medicine | 上海拓界生物医药科技有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-113045407-A | Secondary metabolism compound of Isaria javanicus strain and application thereof | 北京师范大学 | 2021-06-29 | — | — | CN | disclosed |
| EP-3573965-B1 | INDANYLAMINOPYRAZINYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2021-06-23 | — | — | EP | disclosed |
| CN-112574212-A | Pyrimido five-membered nitrogen heterocyclic derivative, preparation method and medical application thereof | 上海拓界生物医药科技有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-112266329-A | Efficient production method of bromhexine hydrochloride | 江西亿友药业有限公司 | 2021-01-26 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |
| US-10865384-B2 | 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2020-12-15 | — | — | US | disclosed |
| CN-107417733-B | Quadridentate ring metal palladium (II) complex phosphorescence luminescent material | 浙江工业大学 | 2020-10-27 | — | — | CN | disclosed |
| CN-111559999-A | Lactone compound and extraction method and application thereof | 陕西科技大学 | 2020-08-21 | — | — | CN | disclosed |
| CN-111559999-A | Lactone compound and extraction method and application thereof | 陕西科技大学 | 2020-08-21 | — | — | CN | disclosed |
| CN-108383811-B | Furanone derivative and extraction method and application thereof | 陕西科技大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-108383811-B | Furanone derivative and extraction method and application thereof | 陕西科技大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-108383824-B | Benzopyrone dimer and extraction method and application thereof | 陕西科技大学 | 2020-04-21 | — | — | CN | disclosed |
| CN-108610333-B | Inducing MDM2 to self-degrade E3 ubiquitin ligase dimer amide micromolecule PROTACs | 绍兴文理学院 | 2020-04-03 | — | — | CN | disclosed |
| CN-110857285-A | Substituted pyrazole compound, preparation method, pharmaceutical composition and application thereof | 天津谷堆生物医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| CN-107964028-B | A kind of cobalt complex and preparation method thereof and the application in the transfer hydrogenation of selective catalysis cyano | TSINGHUA UNIVERSITY (CN) | 2019-10-29 | — | — | CN | disclosed |
| CN-106061990-B | A kind of abiraterone derivative and preparation method thereof and medical usage | 四川海思科制药有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110214135-A | Indanyl Aminopyrazine basic ring propanecarboxylic acid, medical composition and its use | 勃林格殷格翰国际有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-109983015-A | 6- pyrazoles-[1,2,4] triazol [4,3-a] pyridine -3- amide derivatives, preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-108640896-B | A kind of Desertorin B and its extracting method and application | 陕西科技大学 | 2019-07-02 | — | — | CN | disclosed |
| CN-108503616-B | A kind of bicoumarin derivative and its extracting method and application | 陕西科技大学 | 2019-07-02 | — | — | CN | disclosed |
| CN-107151310-B | Conjugated polymer and the conjugated polymer containing ester bond and its preparation method and application | 中国科学院化学研究所 | 2019-05-21 | — | — | CN | disclosed |
| US-10253004-B2 | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-04-09 | — | — | US | disclosed |
| CN-109053564-A | The asymmetric piperidines ketone compound and preparation method thereof that N- benzenesulfonyl replaces | 滨州医学院 | 2018-12-21 | — | — | CN | disclosed |
| CN-105646637-B | A kind of abiraterone derivative and preparation method thereof and medical usage | 四川海思科制药有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-108997311-A | Bis- aryl methylene -4- the piperidones of 3,5- and preparation method thereof that asymmetric 4- pyridine replaces | 滨州医学院 | 2018-12-14 | — | — | CN | disclosed |
| CN-108997310-A | Bis- aryl methylene -4- the piperidones of 3,5- and preparation method thereof that asymmetric 3- pyridine replaces | 滨州医学院 | 2018-12-14 | — | — | CN | disclosed |
| CN-108640896-A | A kind of Desertorin B and its extracting method and application | 陕西科技大学 | 2018-10-12 | — | — | CN | disclosed |
| CN-108503616-A | A kind of bicoumarin derivative and its extracting method and application | 陕西科技大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-108383811-A | A kind of furanone derivatives and its extracting method and application | 陕西科技大学 | 2018-08-10 | — | — | CN | disclosed |
| CN-108383811-A | A kind of furanone derivatives and its extracting method and application | 陕西科技大学 | 2018-08-10 | — | — | CN | disclosed |
| CN-108383824-A | A kind of benzopyrone dimer and its extracting method and application | 陕西科技大学 | 2018-08-10 | — | — | CN | disclosed |
| WO-2018138026-A1 | INDANYLAMINOPYRAZINYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-08-02 | — | — | WO | disclosed |
| US-20180208560-A1 | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-07-26 | — | — | US | disclosed |
| CN-108191742-A | Bis- aryl methylene -4- piperidines ketone compounds of 3,5- of 4- P-acetamido benzene sulfonyls base substitution and preparation method thereof | 滨州医学院 | 2018-06-22 | — | — | CN | disclosed |
| CN-108191750-A | Bis- aryl methylene-N- benzenesulfonyl -4- piperidines ketone compounds of 3,5- and preparation method thereof | 滨州医学院 | 2018-06-22 | — | — | CN | disclosed |
| CN-108191751-A | Bis- aryl methylene -4- piperidines ketone compounds of 3,5- of 4- fluorophenylsulphonyls substitution and preparation method thereof | 滨州医学院 | 2018-06-22 | — | — | CN | disclosed |
| CN-107964028-A | A kind of cobalt complex and preparation method thereof and the application in the transfer hydrogenation of selective catalysis cyano group | 清华大学 | 2018-04-27 | — | — | CN | disclosed |
| CN-105531277-B | Pyrrolo-imidazole ring derivatives and their use in medicine | 四川海思科制药有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-107151310-A | Conjugated polymer and conjugated polymer containing ester bond and its preparation method and application | 中国科学院化学研究所 | 2017-09-12 | — | — | CN | disclosed |
| US-20170166867-A1 | 2,4,5-TRI-SUBSTITUTED AZOLE-BASED CASEIN KINASE 1 INHIBITORS AS INDUCERS FOR CARDIOMYOGENESIS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-06-15 | — | — | US | disclosed |
| EP-2805947-B1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2017-02-22 | — | — | EP | disclosed |
| CN-103304552-B | Substituted pyridine compounds and using method thereof and purposes | 广东东阳光药业有限公司 | 2016-12-28 | — | — | CN | disclosed |
| EP-3102207-A1 | 2,4,5-TRI-SUBSTITUTED AZOLE-BASED CASEIN KINASE 1 INHIBITORS AS INDUCERS FOR CARDIOMYOGENESIS | Agency For Science, Technology And Research (SG) | 2016-12-14 | — | — | EP | disclosed |
| US-9493453-B2 | Piperazinyl pyrimidine derivatives, preparation method and use thereof | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2016-11-15 | — | — | US | disclosed |
| CN-106061990-A | Abiraterone derivative, and preparation method therefor and medical applications thereof | 四川海思科制药有限公司 | 2016-10-26 | — | — | CN | disclosed |
| EP-2560655-B1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME (US) | 2016-08-24 | — | — | EP | disclosed |
| CN-105531277-A | Pyrrolo-imidazole ring derivatives and their use in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-04-27 | — | — | CN | disclosed |
| CN-103435457-B | A kind of method of separation and purification 1403B from fermented liquid | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-02-03 | — | — | CN | disclosed |
| WO-2015119579-A1 | 2,4,5-TRI-SUBSTITUTED AZOLE-BASED CASEIN KINASE 1 INHIBITORS AS INDUCERS FOR CARDIOMYOGENESIS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-08-13 | — | — | WO | disclosed |
| CN-103304396-B | Method for separating and purifying 1403C from fermentation liquid of 1403C | SHANGHAI INST PHARM INDUSTRY | 2015-06-24 | — | — | CN | disclosed |
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-07 | — | — | US | disclosed |
| US-9006433-B2 | Substituted pyrimidines | MERCK SHARP & DOHME CORP. (US) | 2015-04-14 | — | — | US | disclosed |
| EP-2805947-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2014-11-26 | — | — | EP | disclosed |
| US-20140057901-A1 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2014-02-27 | — | — | US | disclosed |
| US-20130165428-A1 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2013-06-27 | — | — | US | disclosed |
| EP-2560655-A1 | SUBSTITUTED PYRIMIDINES | Merck Sharp & Dohme Corp. (US) | 2013-02-27 | — | — | EP | disclosed |
| US-20130018053-A1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120252782-A1 | Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions | BOEHRINGER INGELHEIM PHARMA GMBH AND CO. KG (DE) | 2012-10-04 | — | — | US | disclosed |
| US-20120252783-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA & CO. KG (DE) | 2012-10-04 | — | — | US | disclosed |
| CN-102114013-B | Compound inhibiting angiogenesis and preparation method and application thereof | SHANDONG ACADEMY OF SCIENCES CHINA JAPAN FRIENDSHIP CT FOR BIOTECHNOLOGY | 2012-09-26 | — | — | CN | disclosed |
| US-20120040982-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA & CO. KG (DE) | 2012-02-16 | — | — | US | disclosed |
| US-20120035158-A1 | Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions | BOEHRINGER INGELHEIM PHARMA GMBH AND CO. KG (DE) | 2012-02-09 | — | — | US | disclosed |
| WO-2011133444-A1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME CORP. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011130908-A1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME CORP. (US) | 2011-10-27 | — | — | WO | disclosed |
| CN-102114013-A | Compound inhibiting angiogenesis and preparation method and application thereof | SHANDONG ACADEMY OF SCIENCES CHINA JAPAN FRIENDSHIP CT FOR BIOTECHNOLOGY | 2011-07-06 | — | — | CN | disclosed |
| US-20110144083-A1 | Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | US | disclosed |
| US-20110144095-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA & CO. KG (DE) | 2011-06-16 | — | — | US | disclosed |
| US-20100204250-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA & CO. KG (DE) | 2010-08-12 | — | — | US | disclosed |
| US-20100173916-A1 | Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20090318514-A1 | Novel Pharmaceutical Compositions | KARO BIO AB (SE) | 2009-12-24 | — | — | US | disclosed |
| US-7629385-B2 | Sphingolipid-derived pharmaceutical compositions | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-12-08 | — | — | US | disclosed |
| EP-2119455-A1 | Tripartite raftophilic structures and their use | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-11-18 | — | — | EP | disclosed |
| EP-1732612-B1 | TRIPARTITE CONJUGATES CONTAINING A STRUCTURE INTERACTING WITH CELL MEMBRANE RAFTS AND THEIR USE | JADO TECHNOLOGIES GMBH (DE) | 2009-09-16 | — | — | EP | disclosed |
| EP-2065040-A2 | Sphingolipids against pathological processes in lipid rafts | Jado Technologies GmbH (DE) | 2009-06-03 | — | — | EP | disclosed |
| EP-2024336-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| US-20080317767-A1 | Tripartitle Raftophilic Strutures and their Use | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2008-12-25 | — | — | US | disclosed |
| EP-1763342-B1 | SPHINGOLIPIDS AGAINST PATHOLOGICAL PROCESSES IN LIPID RAFTS | JADO TECHNOLOGIES GMBH (DE) | 2008-12-17 | — | — | EP | disclosed |
| US-20080090913-A1 | Sphingolipid-Derived Phamaceutical Compositions | JADO TECHNOLOGIES GMBH (DE) | 2008-04-17 | — | — | US | disclosed |
| WO-2007128492-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2007-11-15 | — | — | WO | disclosed |
| EP-1181014-B1 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1763342-A2 | SPHINGOLIPIDS AGAINST PATHOLOGICAL PROCESSES IN LIPID RAFTS | Jadolabs Gmbh (DE) | 2007-03-21 | — | — | EP | disclosed |
| CN-1303052-C | Process for preparing Danshensu | DALIAN CHEMICAL PHYSICS INST (CN) | 2007-03-07 | — | — | CN | disclosed |
| EP-1732612-A1 | TRIPARTITE CONJUGATES CONTAINING A STRUCTURE INTERACTING WITH CELL MEMBRANE RAFTS AND THEIR USE | Jadolabs Gmbh (DE) | 2006-12-20 | — | — | EP | disclosed |
| US-20060247226-A1 | XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | HIMMELSBACH FRANK | 2006-11-02 | — | — | US | disclosed |
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-20060205711-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-09-14 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| EP-1095155-B1 | METHODS FOR ENHANCING THE CONTENT OF SULFUR COMPOUNDS IN PLANTS | MAX PLANCK GESELLSCHAFT (DE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2006002909-A2 | SPHINGOLIPIDS AGAINST PATHOLOGICAL PROCESSES IN LIPID RAFTS | JADOLABS GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |
| WO-2005097199-A1 | TRIPARTITE CONJUGATES CONTAINING A STRUCTURE INTERACTING WITH CELL MEMBRANE RAFTS AND THEIR USE | JADOLABS GMBH (DE) | 2005-10-20 | — | — | WO | disclosed |
| US-20050222126-A1 | Antiangiogenic compounds and an assay for inhibitors of cell invasion | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2005-10-06 | — | — | US | disclosed |
| CN-1670008-A | Process for preparing Danshensu | DALIAN CHEMICAL PHYSICS INST (CN) | 2005-09-21 | — | — | CN | disclosed |
| US-6927227-B2 | Heterocyclic containing biphenyl aP2 inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-09 | — | — | US | disclosed |
| US-20040087587-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-06 | — | — | US | disclosed |
| US-20040077645-A1 | Dipeptidyl aminopeptidase inhibitors; diabetes mellitus, arthritis, obesity, allograft transplantation and osteoporosis treatment | BOEHRINGER INGELHEIM PHARMA GMBH & CO KG (DE) | 2004-04-22 | — | — | US | disclosed |
| WO-2004005298-A1 | DERIVATIVES OF RIFABUTINE USEFUL AS ANTIMICROBIAL AGENTS | INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL (PT) | 2004-01-15 | — | — | WO | disclosed |
| EP-1355893-A2 | ANTIANGIOGENIC COMPOUNDS AND AN ASSAY FOR INHIBITORS OF CELL INVASION | The University of British Columbia (CA) | 2003-10-29 | — | — | EP | disclosed |
| US-20030199563-A1 | Heterocyclic containing biphenyl aP2 inhibitors and method | ROBL JEFFREY A (US) | 2003-10-23 | — | — | US | disclosed |
| US-6608239-B1 | Recombinant DNA molecule comprising nucleic acid molecule encoding a protein having serine acetyl-transferase activity and a protein having cysteine synthase activity | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2003-08-19 | — | — | US | disclosed |
| US-6548529-B1 | AP2 (adipocyte fatty binding protein); biphenyl-substituted pyrazoles of given formula; treating diabetes and related diseases; mixtures with other antidiabetic agents such as metformin, glyburide, troglitazone and/or insulin | BRISTOL-MYERS SQUIBB COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-20030004149-A1 | Antiangiogenic compounds and an assay for inhibitors of cell invasion | UNIVERSITY OF BRITISH COLUMBIA, THE (CA) | 2003-01-02 | — | — | US | disclosed |
| US-20020198205-A1 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-26 | — | — | US | disclosed |
| US-6428820-B2 | EXTRACTING FLOWERING TOP OF HYPERCIUM PERFORATUM (ST.-JOHNS-WORT) WITH ALCOHOL OR ACETONE SOLVENT, FILTERING, CONCETRATING THEN DILUTING THE EXTRACT WITH WATER OR WATER-ALCOHOL SOLVENT, THEN EXTRACTING WITH ALIPHATIC ESTER | INDENA S.P.A. (IT) | 2002-08-06 | — | — | US | disclosed |
| WO-2002058679-A2 | ANTIANGIOGENIC COMPOUNDS AND AN ASSAY FOR INHIBITORS OF CELL INVASION | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2002-08-01 | — | — | WO | disclosed |
| US-20020082420-A1 | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-06-27 | — | — | US | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| EP-1181014-A4 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2002-06-05 | — | — | EP | disclosed |
| CN-1345239-A | Heterocyclic containing biphenyl alpha P2 inhibitors and method | BRISTOL MYERS SQUIBB CO (US) | 2002-04-17 | — | — | CN | disclosed |
| EP-1181014-A1 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| EP-1095155-A1 | MEANS AND METHODS FOR ENHANCING THE CONTENT OF SULFUR COMPOUNDS IN PLANTS | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2001-05-02 | — | — | EP | disclosed |
| US-20010000326-A1 | Extracts of hypericum perforatum and formulations containing them | INDENA S.P.A. (IT) | 2001-04-19 | — | — | US | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |
| WO-2000059506-A1 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-12 | — | — | WO | disclosed |
| US-6127378-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AS BRONCHIAL THERAPEUTICS, AN ANTIINFLAMMATORY AGENT TREATING ASTHMA PROPHYLAXIS, SKIN DISORDERS, INTESTINE DISORDERS, EYE DISORDERS, CENTRAL NERVOUS SYSTEM DISORDERS, JOINTS DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |
| WO-2000001833-A1 | MEANS AND METHODS FOR ENHANCING THE CONTENT OF SULFUR COMPOUNDS IN PLANTS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-01-13 | — | — | WO | disclosed |
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5962507-A | BLOCKING CHOLESTEROL BIOSYNTHESIS | DR. KARL THOMAE GMBH (DE) | 1999-10-05 | — | — | US | disclosed |
| US-5821240-A | ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1998-10-13 | — | — | US | disclosed |
| US-5726205-A | ANTICHOLESTEROL AGENTS | KARL THOMAE GMBH (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5707989-A | ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | DR. KARL THOMAE GMBH (DE) | 1998-01-13 | — | — | US | disclosed |
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5455273-A | Antiacholesterol agents | KARL THOMAE GMBH (DE) | 1995-10-03 | — | — | US | disclosed |
| EP-0299034-B1 | PROCESS FOR THE PREPARATION OF COMPOUNDS WITH ANTIULCER ACTION | JANUS FARMA SRL (IT) | 1994-01-12 | — | — | EP | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| WO-1993011154-A1 | INHIBITORS OF THE CONVERSION OF BIG ENDOTHELIN TO ENDOTHELIN | BERLEX LABORATORIES, INC. (US) | 1993-06-10 | — | — | WO | disclosed |
| US-5057605-A | SIALOCYLGLYCEROLIPIDS AND METHOD FOR PREPARING THE SAME | MECT CORPORATION (JP) | 1991-10-15 | — | — | US | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| CN-1033056-A | Saliva acylglyceride and preparation method thereof | KANTO ISHI PHARMA CO LTD (JP) | 1989-05-24 | — | — | CN | disclosed |
| EP-0315973-A2 | Sialocylglycerolipids and method for preparing the same | MECT CORPORATION (JP) | 1989-05-17 | — | — | EP | disclosed |
| EP-0299034-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS WITH ANTIULCER ACTION. | JANUS FARMA SRL (IT) | 1989-01-18 | — | — | EP | disclosed |
| WO-1988005436-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS WITH ANTIULCER ACTION | JANUS FARMACEUTICI SRL (IT) | 1988-07-28 | — | — | WO | disclosed |
| US-4748239-A | VASODILATORS | E. R. SQUIBB & SONS, INC. (US) | 1988-05-31 | — | — | US | disclosed |
| US-4748239-A | VASODILATORS | E. R. SQUIBB & SONS, INC. (US) | 1988-05-31 | — | — | US | disclosed |