Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553199 | 0.84 | ALDH1A1 (0.35) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL7881244 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL7873623 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL7876395 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL5547613 | 0.80 | KDM4E (0.31) | ALDH1A1KDM4E | |
| SCHEMBL6182752 | 0.75 | NPSR1 (0.55) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL8030601 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL7005800 | 0.74 | NPSR1 (0.53) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL7008693 | 0.72 | CYP1A2 (0.51) | ALDH1A1KDM4ENPSR1MAPTKMT2A | |
| SCHEMBL7007726 | 0.72 | CYP1A2 (0.51) | ALDH1A1KDM4ENPSR1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282469-B2 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | BAYER CROPSCIENCE GMBH (DE) | 2007-10-16 | — | — | US | disclosed |
| EP-1527067-B1 | 4-TRIFLUOROMETHYLPYRAZOLYL SUBSTITUTED PYRIDINES AND PYRIMIDINES | BAYER CROPSCIENCE GMBH (DE) | 2006-10-04 | — | — | EP | disclosed |
| EP-1527067-A1 | 4-TRIFLUOROMETHYLPYRAZOLYL SUBSTITUTED PYRIDINES AND PYRIMIDINES | Bayer CropScience GmbH (DE) | 2005-05-04 | — | — | EP | disclosed |
| US-20040082475-A1 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | BAYER CROPSCIENCE AG (DE) | 2004-04-29 | — | — | US | disclosed |
| WO-2004013129-A1 | 4-TRIFLUOROMETHYLPYRAZOLYL SUBSTITUTED PYRIDINES AND PYRIMIDINES | BAYER CROPSCIENCE GMBH (DE) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082475-A1 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | NOX4, CYP4X1, ROS1 | ALDH1A1 394/4885KDM4E 1306/4885NPSR1 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.