Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551399 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4ESMN1; SMN2NPSR1MAPT | |
| SCHEMBL5382636 | 0.76 | RXRA (0.36) | ALDH1A1KDM4ESMN1; SMN2GRM2HPGD | |
| SCHEMBL7873623 | 0.73 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPSR1MAPTSLC6A2 | |
| SCHEMBL5395664 | 0.72 | GRIN1 (0.40) | GRM2RXRAGRIN1GRIN2BALOX5AP | |
| SCHEMBL7876395 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPSR1MAPTSLC6A2 | |
| SCHEMBL7470124 | 0.70 | PPP1CA (0.35) | ALDH1A1GRIN1GRIN2BDRD1ALOX5AP | |
| SCHEMBL7881244 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPSR1MAPTSLC6A2 | |
| SCHEMBL8720836 | 0.68 | KMT2A (0.36) | ALDH1A1NPSR1MAPTDRD1KMT2A | |
| SCHEMBL27894825 | 0.68 | LOXL2 (0.50) | ALOX5APFEN1TGFBR1 | |
| SCHEMBL25315538 | 0.67 | IDH1 (0.43) | GRM2DRD1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282469-B2 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | BAYER CROPSCIENCE GMBH (DE) | 2007-10-16 | — | — | US | disclosed |
| EP-1527067-B1 | 4-TRIFLUOROMETHYLPYRAZOLYL SUBSTITUTED PYRIDINES AND PYRIMIDINES | BAYER CROPSCIENCE GMBH (DE) | 2006-10-04 | — | — | EP | disclosed |
| EP-1527067-A1 | 4-TRIFLUOROMETHYLPYRAZOLYL SUBSTITUTED PYRIDINES AND PYRIMIDINES | Bayer CropScience GmbH (DE) | 2005-05-04 | — | — | EP | disclosed |
| US-20040082475-A1 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | BAYER CROPSCIENCE AG (DE) | 2004-04-29 | — | — | US | disclosed |
| WO-2004013129-A1 | 4-TRIFLUOROMETHYLPYRAZOLYL SUBSTITUTED PYRIDINES AND PYRIMIDINES | BAYER CROPSCIENCE GMBH (DE) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082475-A1 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | NOX4, CYP4X1, ROS1 | ALDH1A1 394/4885KDM4E 1306/4885SMN1; SMN2 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.