Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 5/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | NQO2 | P16083 | 2/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.48 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12919978 | 0.85 | CYP17A1 (0.60) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 | |
| SCHEMBL8577619 | 0.80 | SMN1; SMN2 (0.70) | CYP17A1CYP11B1CYP11B2HSD17B1HSD17B2 | |
| SCHEMBL3786463 | 0.78 | NQO2 (0.73) | CYP17A1CYP11B1CYP11B2HSD17B1HSD17B2 | |
| SCHEMBL13986211 | 0.78 | NQO2 (0.55) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 | |
| SCHEMBL12999591 | 0.77 | NPC1 (0.69) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 | |
| SCHEMBL5553122 | 0.76 | CYP17A1 (0.51) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 | |
| SCHEMBL4654909 | 0.76 | ALDH1A1 (0.67) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 | |
| SCHEMBL14384612 | 0.76 | CNR1 (0.71) | CYP17A1CYP11B1CYP11B2HSD17B1HSD17B2 | |
| SCHEMBL969807 | 0.76 | RAB9A (0.65) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 | |
| SCHEMBL1749196 | 0.75 | MEN1 (0.59) | CYP17A1CYP11B1CYP11B2ADAMTS4HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756058-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005105744-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. | 2005-11-10 | — | — | WO | claimed |
| US-20050245543-A1 | Histamine-3 receptor antagonists | PFIZER INC | 2005-11-03 | — | — | US | disclosed |
| EP-1527077-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004016614-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | HRH3, HRH4, HRH2 | CYP17A1 1841/4885CYP11B1 835/4885CYP11B2 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.