Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797314 | 0.98 | TSHR (0.37) | PTGS2TSHRHSD11B1CYP19A1MGLL | |
| SCHEMBL5822590 | 0.95 | PTGS2 (0.38) | PTGS2TSHRCYP19A1MGLLFAAH | |
| SCHEMBL5797074 | 0.91 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL5798472 | 0.90 | PTGS2 (0.38) | PTGS2HSD11B1CYP19A1MGLLFAAH | |
| SCHEMBL5800883 | 0.89 | PTGS2 (0.45) | PTGS2 | |
| SCHEMBL5800966 | 0.89 | PTGS2 (0.38) | PTGS2HSD11B1MGLL | |
| SCHEMBL5820012 | 0.88 | PTGS2 (0.36) | PTGS2HSD11B1CYP19A1MGLLFAAH | |
| SCHEMBL5559153 | 0.87 | TSHR (0.36) | PTGS2TSHRHSD11B1CYP19A1HPGD | |
| SCHEMBL5799094 | 0.87 | L3MBTL1 (0.38) | PTGS2HSD11B1MGLL | |
| SCHEMBL5798703 | 0.86 | PTGS2 (0.43) | PTGS2TSHRCYP19A1HPGDHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |