Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 3/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | NMT2 | O60551 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5529889 | 1.00 | SIGMAR1 (0.45) | SIGMAR1TSHRCYP1A2ALDH1A1KMT2A | |
| SCHEMBL3514223 | 0.84 | ALDH1A1 (0.46) | TSHRCYP1A2ALDH1A1KMT2AMETAP2 | |
| SCHEMBL1065289 | 0.84 | ALDH1A1 (0.46) | TSHRCYP1A2ALDH1A1KMT2AMETAP2 | |
| SCHEMBL11805171 | 0.76 | PLA2G2C (0.44) | KMT2A | |
| SCHEMBL9322958 | 0.76 | PLA2G2C (0.44) | KMT2A | |
| SCHEMBL7916905 | 0.74 | CA1 (0.44) | — | |
| Urea SCHEMBL1837240 | 0.73 | CYP1A2 (0.63) | SIGMAR1CYP1A2KMT2AKDM5APHF8 | |
| SCHEMBL16059756 | 0.73 | CA2 (0.50) | SIGMAR1CYP1A2ALDH1A1KMT2AKDM5A | |
| SCHEMBL8513654 | 0.72 | GNAI3 (0.40) | KMT2AEPHX1 | |
| SCHEMBL22131838 | 0.72 | METAP2 (0.46) | SIGMAR1TSHRMETAP2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814875-A2 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | The Regents of the University of California (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1608319-A4 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | UNIV CALIFORNIA (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006045119-A9 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | UNIV CALIFORNIA (US) | 2006-05-26 | — | — | WO | disclosed |
| WO-2006045119-A2 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-04-27 | — | — | WO | disclosed |
| EP-1608319-A2 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | The Regents of the University of California (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1575489-A2 | USE OF INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO INHIBIT VASCULAR SMOOTH MUSCLE CELL PROLIFERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004089296-A2 | IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-10-21 | — | — | WO | disclosed |
| WO-2003061597-A2 | USE OF INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO INHIBIT VASCULAR SMOOTH MUSCLE CELL PROLIFERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-07-31 | — | — | WO | disclosed |