Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726306 | 0.75 | NR3C1 (0.45) | KDM4ECYP3A4ADORA2ACYP2C19LMNA | |
| SCHEMBL3201018 | 0.71 | NPC1 (0.46) | KDM4ELMNAGAATP53MAPK1 | |
| SCHEMBL8557058 | 0.69 | FFAR2 (0.41) | KDM4ELMNATP53ALDH1A1HPGD | |
| SCHEMBL27930079 | 0.69 | LMNA (0.50) | KDM4ELMNAGAATP53ALDH1A1 | |
| SCHEMBL12503021 | 0.69 | SCD (0.47) | KDM4ELMNAGAAALDH1A1FFAR1 | |
| SCHEMBL3201982 | 0.68 | TRPM8 (0.45) | KDM4ELMNAGAATP53ALDH1A1 | |
| SCHEMBL2772989 | 0.68 | LMNA (0.51) | LMNATP53ALDH1A1GLAHPGD | |
| SCHEMBL22074370 | 0.68 | NOTUM (0.53) | LMNATP53USP2MAPK1NPC1 | |
| SCHEMBL1896858 | 0.67 | LMNA (0.53) | LMNAALDH1A1GLAKMT2ANPSR1 | |
| SCHEMBL2727288 | 0.67 | GAA (0.44) | KDM4ECYP3A4ADORA2ACYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658288-B1 | 2-AMINO-5-BENZOYLTHIAZOLE NPY ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-12-05 | — | — | EP | claimed |