Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244518 | 0.90 | MEN1 (0.33) | RAB9ASMN1; SMN2KDM4EPOLBNAMPT | |
| SCHEMBL5243261 | 0.89 | HTR1A (0.41) | RAB9ASMN1; SMN2NAMPTHTR1AMEN1 | |
| SCHEMBL5242810 | 0.88 | MEN1 (0.34) | RAB9ASMN1; SMN2KDM4EPOLBNAMPT | |
| SCHEMBL5788866 | 0.83 | PKM (0.45) | ROCK1KDM4ETMPRSS2GAAALDH1A1 | |
| SCHEMBL4637685 | 0.82 | NR1H2 (0.39) | SMN1; SMN2KDM4EPOLBHTR1AMEN1 | |
| SCHEMBL2124647 | 0.81 | ESR1 (0.44) | KDM4EPOLBHTR1ATSHRALDH1A1 | |
| SCHEMBL5556540 | 0.81 | RAB9A (0.44) | RAB9ACHEK1AURKADAPK3JAK2 | |
| SCHEMBL5170176 | 0.79 | SLC18A2 (0.36) | SMN1; SMN2KDM4EPOLBNAMPTHTR1A | |
| SCHEMBL5170187 | 0.78 | SLC18A2 (0.36) | SMN1; SMN2KDM4EPOLBHTR1AMEN1 | |
| SCHEMBL5551732 | 0.78 | MTNR1B (0.50) | KDM4EPOLBHTR1ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751163-A2 | COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005118549-A2 | COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2005-12-15 | — | — | WO | disclosed |